A Single Vaccine Effective For Hepatitis A and B

Important Facts about Twinrix

How does the Vaccine Work?

Twinrix is a vaccine that has the capacity of providing active immunity against both hepatitis A and hepatitis B infections. It is given according to the following schedule: a starting dosage then another dose at 1 month and the third one at 6 months. The same can be given in 4 doses, with the first dose, then the second at 7 days, third at 21 to 30 days, and fourth at the completion of 12 months.

What is the Reasoning behind its Administration?

This strong vaccine combination can help avoid both hepatitis A infection (HAV) and hepatitis B infection (HBV) contamination with a single administration (at 3 or 4 doses). Individuals get the immunizations together instead of going for separate shots. The US-FDA (U.S Food and Drug Administration) has affirmed its utilization just for individuals age 18 and above who are in danger of contamination with the HAV and HBV. These incorporate the following individuals:

  • People who make trips to territories that have moderate to high incidence of HAV and HBV. These include Asia, the Caribbean, Africa, America, the Middle East, Europe, and the former Soviet Union.
  • Suffering from a long term (chronic) liver ailment.
  • Uses unlawful injectable medications.
  • Have anal sex with a sexual partner.
  • People having to face the infection as an occupational hazard, such as lab specialists, individuals who give emergency medicinal support, and day-care health workers.
  • Have clotting component issues and get blood products.

For How Long is it Effective?

Research has revealed that you can achieve lifelong immunity against hepatitis B infection. On the other hand, the hepatitis A vaccine remains active for a minimum period of 25 years in grown-ups and in children it remains for about 14 years.

Clinical Side Effects

All medicines have symptoms and effects. However, numerous individuals don't feel the symptoms, or they can manage them. Get some information about the symptoms of each one solution that you take. General side effects associated with a drug are given on the label. Symptoms are likewise recorded in the data that accompanies your prescription.

Here are some imperative things to contemplate and keep in mind:

  • Typically, the benefits of any medicine are way more important than any mild side effects.
  • Symptoms may subside on their own after some time in most of the cases.

In the event of severe reactions, you must call your specialist, especially if you have problems like the following:

  • Difficulty in breathing
  • Swollen face, lips, tongue, or throat.
  • Hives: This is also called urticaria. There are swollen areas with pale red itchy bumps on the skin all over the body.

Twinrix immunization has side effects like:

  • Soreness at the injected part.
  • Headache.
  • Weakness.
  • Diarrhea
  • Vomiting sensation (nausea)
  • Fever

Things to Remember about Twinrix and Hepatitis:

  • Allergies to Twinrix or other vaccines: Twinrix must not be given to individuals who are allergic to vaccine components. Inform your doctor or the pharmacist if you had any previous episode of allergic reaction after vaccination.
  • Get ready before travel: To get the best assurance of protection before travel, you may require two shots of Twinrix before you take-off. If it is not possible to get two shots, get a shot of hepatitis A vaccine as an alternative for the combination vaccine. This will safeguard you better against hepatitis A.
  • Pregnant or lactating women: If you are pregnant or breastfeeding or if you want to get pregnant, don't consume any drugs or get yourself immunized unless your doctor advises you to. You must understand that your baby may be harmed from some of the drugs. Don't go for strong over-the-counter drugs, vitamins, herbs, or supplements without consulting your doctor first.

Remember to receive your vaccines on time for increased effectiveness. An easy way to remember is to note the due dates on your personal calendar. When missing any of your vaccines, inform your doctor at the earliest so that your vaccination can be scheduled accordingly.


Nothdurft HD, Dietrich M, Zuckerman JN, Knobloch J, Kern P, Sänger R. Rapid protection against hepatitis A and B using an accelerated vaccination schedule: comparison of combined vaccine, Twinrix, with separate vaccines. BioDrugs. 2003;17 Suppl 1:15-8.

Stratton K, Ford A, Rusch E, et al., editors. Adverse Effects of Vaccines: Evidence and Causality. Washington (DC): National Academies Press (US); 2011 Aug 25. 8, Hepatitis B Vaccine.

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