Your Guide to Alcohol Allergies and Intolerances

When Your Symptoms Are Not Just a Hangover

Group of friends toasting with drinks
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Do you seem to get sick every time you drink alcohol? No, not for that reason (a hangover doesn't count). Instead of hangover symptoms, do you experience food allergy symptoms or odd digestive or other physical symptoms after only one or two drinks?

If that sounds familiar, you may be dealing with one of the many different types of alcohol allergies and intolerances. While true allergies to ethanol (the type of alcohol found in intoxicating beverages) are rare, alcoholic beverages include a number of ingredients that can cause allergies and intolerances.

There's some good news, too. While some of these allergies may require you to quit drinking entirely, there are workarounds for the others.

Issues With Gluten and Wheat

Gluten, the protein that triggers celiac disease reactions, is found in malted barley, which is used to make beer and some hard ciders (though most ciders are gluten-free). Some beer also contains wheat (either in addition to or instead of barley). Some alcoholic beverages, on the other hand, are distilled, meaning that they have been condensed and evaporated. Common distilled beverages are sometimes made from wheat, rye, and barley including vodka, whiskey, gin, and bourbon.

The American Dietetic Association considers distilled spirits safe for people with celiac disease. However, this is a controversial topic, since many people with celiac or non-celiac gluten sensitivity do report reactions to alcoholic beverages distilled from gluten grains.

 Little research has been done on the effects of distilled spirits made from wheat on people with wheat allergies, but the European Food Safety Authority considers them safe.Nonetheless, if you feel uncomfortable with the idea of consuming gluten grain-based alcohol, try potato-based or grape-based vodka.

It's also possible to find gluten-free whiskey made from sorghum, a gluten-free grain.

Because the gluten-free commercial market has grown so much, many manufacturers make alcoholic beverages that are labeled as gluten-free. For example, these beers are made from entirely gluten-free ingredients. Common alcoholic beverages that are naturally gluten-free include wine and most brandies. Most liqueurs and some wine coolers are gluten-free as well, but it's wise to check labels or manufacturer websites for these since there are exceptions.

Histamine Intolerance

Many foods, including aged cheese and red wine, are high in histamine, the same chemical involved in a number of allergic reactions in the body.

Your body has two enzymes that are supposed to break down histamine, but sometimes these enzymes don't work as well as they should. When this occurs, it can cause a variety of histamine intolerance symptoms, including the so-called "red wine headache." There also is some evidence for histamine being associated with migraines.

While red wine is especially high in histamines, all alcoholic beverages are high in histamine. Antihistamines like Benadryl may be somewhat useful in treating histamine intolerance symptoms when they occur, but the best treatment for histamine intolerance is a histamine-free — and, therefore, alcohol-free — diet.

Other histamine-rich foods include cured meats, spinach, tomatoes, and fermented foods like kefir.

Sulfite Allergies

A group of sulfur-containing compounds known as sulfites occur naturally in wine and beer, and they help inhibit the growth of harmful bacteria. Vintners sometimes add additional sulfites to wines as preservatives. In susceptible individuals, sulfites can trigger asthma attacks or even anaphylactic shock.

For most sulfite-sensitive people, very low amounts of sulfites do not trigger an asthma attack, but as amounts go up, so do the chances of experiencing a reaction. U.S. labeling laws require any food with sulfite concentrations greater than 10 parts per million (ppm) to be listed on the label using the term "contains sulfites," and for the vast majority of people, concentrations too low to require this warning don't cause problems.

However, if your allergist has alerted you that you may be at risk of anaphylaxis or other systemic reactions due to sulfites, you should avoid all wine. There is no such thing as a truly sulfite-free wine. While organic wines are not allowed to include added sulfites, by law, some do include enough natural sulfites to be problematic for some asthmatic individuals.

Yeast Allergies

The type of yeast used to ferment alcoholic beverages is a one-celled fungus commonly known as brewer's yeast. The scientific name is Saccharomyces cerevisiae, and it's the same yeast that is used to make bread rise.

Allergies to Saccharomyces cerevisiae have been well-documented in medical literature and are most likely to occur in people who have mold allergies. Brewer's yeast is used in all fermented alcoholic beverages — beer, wine, hard cider, sake, kvass, and other similar beverages — and individuals with yeast allergies should avoid them.

There has been very little research done on yeast allergies and distilled spirits. If you are allergic to yeast and would like to make these beverages part of your diet, you should discuss further allergy testing with your allergist.

It's important to note that brewer's yeast isn't the same organism as Candida albicans, which some alternative health practitioners have speculated can cause everything from chronic fatigue to depression. While mainstream practitioners agree that Candida albicans can cause acute infections like thrush, most reject the theory that chronic candidiasis is responsible for widespread health problems.

Grape Allergies

Grape allergies are rare, but they have been identified in medical literature. In addition to wine, individuals with grape allergies will need to avoid Armagnac, cognac, ouzo, vermouth, port, champagne, most wine coolers, and packaged martini mixes. Some possible alternatives to wine and grape-based spirits include Japanese plum wine, which has a sweet taste somewhat like Moscato, and Calvados, which is apple brandy.

Corn Allergies and Intolerances

To date, the question of whether distilled alcohol made from corn is safe for people with corn allergies (as other distilled grain alcohols appear to be for people with other grain allergies) has received very little attention in peer-reviewed medical literature.

A 1999 case study on a patient who had demonstrated corn allergies and anaphylaxis triggered by beer appeared to show that corn-derived distilled alcohol was safe for patients with corn allergies. This case study was cited by the European Food Safety Authority in their position paper stating that distilled alcohol derived from corn was probably safe for patients with corn allergies, especially since scientists could not demonstrate the presence of proteins (the portion of corn that triggers allergic reactions) after the distillation process.

But given that the clinical evidence on corn and distilled alcohol is so scant, you may wish to talk to your allergist before adding corn-derived distilled alcohol to your diet. Bourbon is always distilled from corn; other distilled spirits that may be distilled from corn include whiskey, gin, moonshine and, rarely, vodka.

People with corn allergies or intolerances should avoid fermented alcohols that are derived from corn. While some beers are safe — they use non-corn cereal grains, water, yeast, and hops — many are not, and currently, U.S. manufacturers are not required to list ingredients on malt beverages (although some do). Wine is safe for corn allergies and intolerances, but Spanish chicha is another fermented corn-based beverage.

One other potential area of concern may be flavorings added to liqueurs or brandies; if full lists of ingredients are unavailable, check manufacturer websites or call customer service before drinking.


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Figueredo, Elena, et al. "Beer Induced Anaphylaxis: Identification of Allergens." Allergy. June 1999 54(6): 630-34. 13 June 2007.

Gupta, Rita. "The Buzz About Wine and Beer Allergy" Allergy & Asthma Advocate Winter 2006. 4 June 2007.

Maintz, Laura and Natalija Novak. "Histamine and Histamine Intolerance." American Journal of Clinical Nutrition. May 2007, 85(5): 1185-96. 4 June 2007.

Schad, Susanne G. et al. "Wine Anaphylaxis in a German Patient: IgE-Mediated Allergy Against a Lipid Transfer Protein of Grapes." International Archives of Allergy and Immunology. Feb. 2005 136(2); 159-64.

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