Allegra and Fruit Juice Concerns

Can I Take Allegra and Fruit Juice Together?

Allegra and fruit juice don't mix.

Allegra (fexofenadine) is a non-sedating oral antihistamine used for the treatment of allergic rhinitis, allergic conjunctivitis, and urticaria/angioedema. Allegra recently became available over-the-counter (OTC) without a prescription in 2011, and is approved for children as young as 2 years old (prescription versions are approved for children as young as 6 months old). Since becoming available OTC and approved for young children, Allegra will likely become even more popular for people with allergy symptoms.

For this reason, it is important for people to know that taking Allegra with various fruit juices, especially orange and grapefruit juice, reduces the absorption of Allegra by more than a third, making the medicine less effective.

Why You Should You Wait Before Taking Allegra and Drinking Juice

Allegra, when taken orally, depends on specialized receptors on cells within the small intestines, called organic anion transporting polypeptides (OATPs), to absorb the medicine into the body. When various fruit juices are present in the small intestines, especially grapefruit, apple or orange juice, these OATPs are unable to absorb Allegra into the body. This effect seems to occur with soft drinks with as little as 5 percent fruit juice. Taking Allegra with fruit juice may decrease the absorption by nearly 40 percent or more, making the medicine far less effective in the treatment of allergy symptoms.

Therefore, the package insert for prescription Allegra, as well as the patient instructions for OTC Allegra, recommend not taking this medication with fruit juices. I would take this a step further and recommend that a person not eat or drink any product containing fruit or fruit juice for a couple of hours before or after taking Allegra.

Doing so would dramatically reduce the effectiveness of the drug and leave a person suffering from uncontrolled allergy symptoms.


Allegra package insert

Bailey G. Fruit Juice Inhibition of Uptake Transport: A New Type of Food-Drug Interaction. Br J Clin Pharmacol. 2010 Nov;70(5):645-55.

Kalliokoski A, Niemi M. Impact of OATP Transporters on Pharmacokinetics. British Journal of Pharmacology (2009) 158, 693–705.

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