Antithyroid Drug - Propylthiouracil - PTU - for Hyperthyroidism

ptu, propylthiouracil, antithyroid drugs, graves disease, hyperthyroidism

Propylthiouracil -- often abbreviated PTU -- is an antithyroid drug, used to treat Graves' disease and hyperthyroidism. PTU is available in the United States only as a generic drug.


According to FDA information, the following are the potential side effects of PTU:

  • rash
  • itching
  • hives
  • abnormal hair loss
  • skin pigmentation
  • swelling
  • nausea
  • heartburn
  • nausea
  • muscle aches
  • numbness
  • loss of ability to taste
  • liver damage


The PTU is the subject of an FDA "Black Box" warning -- considered among the most serious warnings. The FDA warning regarding PTU is due to concerns regarding severe liver injury.

Some of the FDA's other warnings regarding PTU include the following:

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