"Arthritis Without Pain - The Miracle of TNF Blockers" Book Review

Must-Read Book Helps with Understanding of Biologic Drugs

Arthritis Without Pain book cover

"Arthritis Without Pain - The Miracle Of TNF Blockers" is an exceptionally well-written resource. The book offers essential information about a class of arthritis drugs, TNF blockers, that first became available in 1998. The book helps the reader fully comprehend how TNF drugs are different from other arthritis medications. Since the first TNF blocker was FDA approved, arthritis patients have had questions -- even those who have had a successful response with one of the TNF drugs.

This book provides the answers.


  • Answers the question - what are TNF blockers and how do they work?
  • Explains the differences between Enbrel (etanercept), Remicade (infliximab), and Humira (adalimumab). Since the book was written, there are two more, Simponi (golimumab) and Cimizi (certolizumab pegol).
  • Spotlights patient experiences. Helps you decide if TNF blockers are for you.
  • Packed with useful information.


  • No cons. Book explains TNF is miracle for many, not for everyone.
  • Written before Simponi and Cimzia were approved but the information applies to those two drugs as well. They just aren't mentioned.


  • Author Scott J. Zashin M.D. - internal medicine and rheumatology - clinical assistant professor.
  • Author M. Laurette Hesser - marketing, communications consultant - special interest in healthcare.
  • A balanced explanation - not understating or overstating TNF blocker benefits and risks.
  • Overview of arthritis presented in easily understood terminology.
  • Information about arthritis medications concisely explains how they work.
  • Book is essential resource for arthritis patients considering a TNF blocker.
  • Book is essential too for arthritis patients already on a TNF blocker - for better understanding.
  • Helps you comprehend the current and future trends in arthritis therapies.
  • Read the book and discuss any questions you have with your rheumatologist.
  • Must-read for people interested in arthritis treatment. Among the best resources on my bookshelf.

Guide Review - Arthritis Without Pain - The Miracle Of TNF Blockers

Book focuses on what is without question the biggest story in the arthritis world in decades - how lives have been renewed because of the breakthrough arthritis treatment known as TNF blockers. The book begins with an overview of arthritis and looks at older, better-known arthritis drugs - NSAIDs, DMARDs, and corticosteroids. The spotlight shines on what the authors call "a revolution in arthritis treatment" - the drugs which became available since 1998 in the U.S. including:

It is Enbrel, Remicade, and Humira (the first three TNF blockers) which the authors dub "the arthritis miracle". A thorough explanation is offered regarding how each of these drugs work and the science behind their evolution.

What the TNF drugs deliver in terms of success is told - "in multiple clinical studies involving tens of thousands of arthritis patients, TNF blockers produced noticeable improvement in 2 of every 3 patients". But, also told is the fact that TNF blockers are not without risks and have possible serious side effects (in about 1 in 1000 patients). Of special interest is "The TNF Blocker Decision Matrix" - a self-test to help you and your doctor decide if TNF blockers are for you, plus information about choosing and starting a TNF blocker, as well as 25 frequently asked questions.

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