Can Transcranial Magnetic Stimulation Treat Alzheimer's Disease?

Transcranial Magnetic Stimulation for Alzheimer's?
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Transcranial Magnetic Stimulation (TMS) is a relatively new way to use magnetism to affect the brain. It is non-invasive, meaning that the procedure does not require any type of surgery; rather, it is conducted by transmitting magnetic pulses through the brain by pressing a machine against the head. Is it possible that this science-fiction-like procedure can help people with Alzheimer's disease?

Most commonly, TMS has been studied as a way to treat depression that won’t respond to antidepressant medications or counseling therapy.

Several studies have been conducted and have shown TMS to be quite effective in reducing the level of depression for people who have not responded to medications.

TMS is currently being researched in a variety of fields, including Alzheimer’s, Parkinson’s, stroke, depression, obsessive-compulsive disorder and more, with varying degrees of effectiveness.

What is Repetitive TMS?

Repetitive TMS (rTMS) is when a series of TMS is performed over time.

TMS and Alzheimer’s Disease

TMS, specifically repetitive TMS (rTMS), has been researched as an intervention for people with Alzheimer’s disease. Several research studies have studied the effect of TMS on people whose cognitive functioning is impaired, whether through vascular dementia, Alzheimer’s, mild cognitive impairment or other types of dementia. Often, the application of rTMS is combined with cognitive training over a period of a few weeks, with testing done prior to the TMS and cognitive training, part way through, at the end of and several months following the TMS and cognitive training.

Research Studies

Researchers conducted a small study involving eight participants who received both rTMS and cognitive training daily for six weeks and then twice a week for the next three months. The participants' cognitive functioning was assessed prior to the start of the study, at six weeks into the study and at four and a half months after the start of the study.

The scores on the Alzheimer Disease Assessment Scale-Cognitive were improved by approximately 4 points both at six weeks into the study and at the four and a half month mark.

Several other studies involving the application of rTMS alone without cognitive training have been conducted with fairly positive results as well. After receiving rTMS, participants in various studies demonstrated improvements in auditory sentence comprehension, action naming, and object naming ability.

Thus far, no side effects have been identified, and the benefits have been demonstrated in people with mild (early stage), moderate (middle-stage) and severe Alzheimer's disease.

Further Clinical Trials Are Needed

It's important to note that more study is needed, as these studies typically have involved smaller numbers of participants and were structured for shorter periods of time. There are multiple clinical trials underway currently to continue the research involving rTMS. You can view those clinical trials at and search under "transcranial magnetic stimulation Alzheimer's" or visit TrialMatch, a service available through the Alzheimer's Association.


Beth Israel Deaconess Medical Center.: A Teaching Hospital of Harvard Medical School. Transcranial Direct Current Stimulation.

European Journal of Neurology. 21 MAR 2012. Prefrontalcortex rTMS enhances action naming in progressive non-fluent aphasia.

European Journal of Neurology. 15.12 (Dec. 2008): p1286. Transcranial magnetic stimulation improves naming in Alzheimer disease patients at different stages of cognitive decline.

International Journal of Alzheimer’s Disease. Transcranial Magnetic Stimulation Studies in Alzheimer's Disease.

Journal of Neural Transmission. 2011 Mar;118(3):463-71. Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease: a proof of concept study.

Psychiatric Neurotherapeutics Program (PNP). McLean Hospital. Harvard Medical School Affiliate. Transcranial Magnetic Stimulation (TMS).

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