Co Q10 - Possible Drug Interactions

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CoQ10 supplements haven't been tested for safety and keep in mind that the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established. See tips on using supplements, but if you're considering the use of CoQ10, talk with your doctor first. Please note that this is only a partial list (please consult your doctor for a complete list).

 Some of the possible herb-drug interactions may include:

Diabetes Medication:

e.g. Insulin, metformin (Glucophage®), glyburide (Diabeta®, Glynase®, Micronase®) may interact with Co q10, because Co q10 has possible blood sugar-lowering effects.

ACE Inhibitors:

e.g. captopril (Capoten®), fosinopril (Monopril®), enalapril (Vasotec®), fosinopril (Monopril®) are medications used to lower blood pressure. Co q10 has been found to lower blood pressure, so it may interact and increase the effects of these drugs.

Beta Blockers:

e.g. atenolol (Tenormin®), metoprolol (Lopressor®, Toprol XL®), propranolol (Inderal®)
Beta-blockers are medications that can lower blood pressure. Co q10 has been found to lower blood pressure, so it may interact and increase the effects of these drugs.

Calcium Channel Blockers:

e.g. nifedipine (Adalat®, Procardia®), verapamil (Calan®, Isoptin®)
Calcium channel blockers are medications that can lower blood pressure.

Co q10 has been found to lower blood pressure, so it may interact and increase the effects of these drugs.

Diuretics:

e.g. hydrochlorothiazide (HydroDIURIL®, Esidrix®, Oretic®), furosemide (Lasix®)
Diuretics can lower blood pressure. Co q10 has been found to lower blood pressure, so it may interact and increase the effects of these drugs.

HMG Co-A Reductase Inhibitors / Statin Drugs:

e.g. atorvastatin (Lipitor®), lovastatin (Mevacor®), pravastatin (Pravachol®)
Statin cholesterol-lowering drugs have been found to lower the body's Co q10 levels.

Anticoagulants:

e.g. Warfarin (Coumadin®)
Co q10 has a similar chemical structure to vitamin K, a vitamin involved in the ability of blood to clot. Co q10 may antagonize the effects of anti-clotting medications such as warfarin or heparin.

Dopamine-Enhancing Drugs:

e.g. carbidopa-levidopa (Atamet®, Parcopa®, Sinemet®)
Co q10 may increase the effects of dopamine, so it may interact with medications that increase dopamine. These drugs are often used to treat depression and Parkinson's disease.

Sources
Griffith, H. Winter. Complete Guide to Prescription and Nonprescription Drugs 2006 Edition. New York: Perigree, 2005.

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