Coffee and Liver Disease: Special Considerations for Hepatitis Patients

What Hepatitis Patients should Comprehend about Coffee

What is the correlation between coffee and liver disease? This is a query that many hepatitis sufferers ponder on, given the recent research maintaining that coffee can be an effective method in helping to avert liver disease. If you read further, you can find out more about liver disease and its supposed relation to coffee consumption. Liver disease is one of the most common types of diseases that affect a large part of the population of the world.

There are numerous types of liver diseases, such as cancer, fatty liver, and hepatitis. Liver cancer, however, is one of the leading causes of death around the globe. Additionally, alcohol has a great role in developing liver diseases. Moreover, most liver diseases can lead to scar tissue, widely recognized as fibrosis, in this important organ. During the early phase of fibrosis, the tasks of the liver may still run as planned, but symptoms may already begin to materialize. Eventually, as the fibrosis advances, the inflammation and the injury of the liver may linger, thus allowing the scar tissue to aggregate. As a result, the fibrosis eventually disrupts the functions of the organ and curbs blood flow, giving way to liver cirrhosis.

Coffee can help reduce the Risk of Developing Liver Cancer

If you are a coffee lover, there’s a substantial likelihood that you can forestall your susceptibility of acquiring liver cancer and other types of liver diseases.

There are studies that have been carried out by medical pundits demonstrating that with heightened coffee consumption, the risk of suffering cancer of the liver gradually diminishes. This finding was observed in individuals who had healthy livers as well as those with prior liver disease. Generally speaking, having at least two cups of coffee a day or even up to five cups each day sinks the danger of getting liver cancer by a major percentage.

Coffee can counter the Progress of Fibrosis

Coffee is linked to a decreased risk of developing hepatitis. Increasing the intake of coffee promotes healthy liver functioning. According to one notable study, patients who gulped more coffee exhibited slower advancement of fibrosis, especially if they were suffering from alcoholic liver disease. When the fibrosis dies down, that in turn effectively helps to prolong the liver’s function. This helps to stop or delay the development of fibrosis.

Potential Mechanisms

Clinical evidence also corroborates that the use of coffee by individuals suffering from liver cancer enhances their condition, even if they suffer from liver cirrhosis and liver fibrosis simultaneously. Various potential mechanisms can also be responsible for such effects, and these are still being studied by most experts. Caffeine, which is often consumed to stave off fatigue, is also very rich in anti-oxidants that can help the body get rid of the toxins and free radicals, which in the end can help the patient get well.

What is the Role of Caffeine in the Liver?

So then, what’s the de facto connection between caffeine and your liver? There is evidence that shows that caffeine, particularly its miniscule elements such as the metabolite paraxanthine, could defeat the synthesis of the connective tissue growth factor (CGTF). This can slow the progress of the liver fibrosis, liver cancer and alcoholic cirrhosis. However, some works of research that dealt with tea, which also contains caffeine, suggest that the mechanism of action might not be dependent on caffeine imperatively.

Essential Compounds of Caffeine that can Reduce Liver Disease

Other compounds existent in coffee are also being ardently investigated. There are two natural coffee compounds, cafestol and kahweol, that are considered to possess anti-carcinogenic (anti-cancer) properties. Hepatitis patients should know that this can help reduce the risk of developing liver cancer. Caffeine-derived acids and phenols are also focal components of coffee that are very rich in properties that can foil the replication of the hepatitis B virus itself. They can be strong constituents that can help one to get rid of the unwelcome effects of liver diseases. Last, evidence insinuates that the moderate consumption of coffee, rather than the full-blown indulgence in it, is related to alleviation of the risk of liver cancer, as well as to a decline in the progress of alcoholic cirrhosis and liver fibrosis.

References: Duarte MP, Laires A, Gaspar J, Leão D, Oliveira JS, Rueff J. Genotoxicity of instant coffee: possible involvement of phenolic compounds. Mutat Res. 1999 Jun 7;442(1):43-51.

Gressner OA, Lahme B, Siluschek M, Gressner AM. Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells. Liver Int. 2009 Jul;29(6):886-97.

Lee KJ, Choi JH, Jeong HG. Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol. 2007 Nov;45(11):2118-25.

Modi AA, Feld JJ, Park Y, Kleiner DE, Everhart JE, Liang TJ, Hoofnagle JH. Increased caffeine consumption is associated with reduced hepatic fibrosis. Hepatology. 2010 Jan;51(1):201-9.

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