Cogentin (Benztropine) Uses for Bipolar Disorder

If your antipsychotic medications are giving you tremors, Cogentin may help

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Cogentin (benztropine) is a drug sometimes used in people with bipolar disorder to treat drug-induced parkinsonism (DIP) from bipolar medications. 

Symptoms of Drug-Induced Parkinsonism

Medications often used to treat bipolar disorder, such as typical and atypical antipsychotic drugscalcium channel blockers, as well as anticonvulsant medications, may cause drug-induced parkinsonism, the medical term for symptoms that mimic Parkinson's disease.

 Drug-induced parkinsonism may cause: 

  • Decrease in facial expressions
  • Difficulty starting and controlling movement
  • Loss or weakness of movement (paralysis)
  • Soft voice
  • Stiffness of the trunk, arms, or legs
  • Tremor

What is Cogentin (Benztropine)? 

Cogentin is an antiparkinsonian drug in a class of drugs called antidyskinetics. It is typically used in the treatment of Parkinson's disease and to control movement side effects of certain drugs, as it improves muscle control and decreases the stiffness and tremors.

Cogentin comes in 0.5, 1, and 2 mg tablets to be taken orally, usually at bedtime, but it may be taken multiple times a day to treat tremors. Your doctor may start you on a small dose to see how you respond. 

Cogentin Contraindications

Cogentin may interact with certain drugs, including antidepressants, sleeping pills, painkillers, antihistamines, anti-diarrheal medications, some antacids, and other medications.

It's important that you speak with your doctor about any potential contraindications. 

Common Side Effects of Cogentin

Check with your doctor if any of the following common side effects don't go away or are bothersome:

  • Blurred vision 
  • Constipation 
  • Decreased sweating
  • Difficult or painful urination (especially in older men)
  • Drowsiness
  • Dryness of mouth, nose, or throat
  • Increased sensitivity of eyes to light
  • Nausea or vomiting

Less Common Side Effects of Cogentin

Check with your doctor if any of the following less common side effects don't go away or are bothersome:

  • Dizziness or lightheadedness when getting up from a lying down or sitting position
  • False sense of well-being (especially in the elderly or with high doses)
  • Headache
  • Loss of memory (especially in the elderly)
  • Muscle cramps
  • Nervousness
  • Numbness or weakness in hands or feet
  • Soreness of mouth and tongue
  • Stomach upset or pain
  • Unusual excitement (more common with large doses of trihexyphenidyl)

When to Contact Your Doctor

Always notify your doctor immediately if you experience these rare side effects of Cogentin:

  • Confusion (more common in the elderly or with high doses)
  • Eye pain
  • Skin rash

Cogentin Symptoms of Withdrawal 

If you need to discontinue using Cogentin, it's important to not discontinue it suddenly but to work with your doctor to taper off your dose gradually, unless there is a medical reason your doctor wants you to stop immediately.

Discontinuing Cogentin can cause withdrawal effects, in either case, so be sure to let your doctor know immediately if you experience any of these symptoms:

  • Anxiety
  • Difficulty in speaking or swallowing
  • Dizziness or lightheadedness when getting up from a lying or sitting position
  • Fast heartbeat
  • Loss of balance control
  • Mask-like face
  • Muscle spasms, especially of the face, neck, and back
  • Restlessness or desire to keep moving
  • Shuffling walk
  • Stiffness of arms or legs
  • Trembling and shaking of hands and fingers
  • Trouble sleeping
  • Twisting movements of body

Cogentin Overdose Effects

If you or a loved one have potentially overdosed on Cogentin, call your local poison control center and/or 911 immediately. Symptoms of overdose include:

  • Clumsiness or unsteadiness
  • Severe drowsiness 
  • Severe dryness of mouth, nose, or throat
  • Fast heartbeat
  • Hallucinations (seeing, hearing, or feeling things that are not there)
  • Mood or mental changes
  • Seizures
  • Shortness of breath or troubled breathing
  • Trouble sleeping
  • Warmth, dryness, and flushing of skin

Other benztropine side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.


"Benztropine Mesylate Oral." MedLine Plus. U.S. National Library of Medicine (2010).

"Benztropine (Oral Route). Mayo Clinic (2015).

"Psychiatric Medications: Benztropine." Stanford Medicine (2016).

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