What Is the Difference Between Retin-A and Retin-A Micro?

Comparing Prescription Acne Medications

Woman applying lotion to face
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Retin-A and Retin-A Micro are both topical prescription medications that your dermatologist may prescribe to treat your acne. Because they have nearly identical names and are manufactured by the same company, you may wonder if they are really the same medication.

Despite the incredibly similar names, Retin-A and Retin-A Micro aren't exactly alike. There are some big differences between the two products.

Take a look at the similarities and differences and how both medications work.

Tretinoin Is the Active Ingredient in Both Retin-A and Retin-A Micro

Both Retin-A and Retin-A Micro contain the same active ingredient, tretinoin. It is a topical retinoid, meaning it's a medication derived from vitamin A. Other topical medications that contain tretinoin include Avita, Altinac, Tretin-X, Renova (mainly prescribed as an anti-wrinkle medication), and Ziana. You can even get generic tretinoin.

Retin-A and Retin-A Micro Work in Essentially the Same Way

Retin-A and Retin-A Micro both work to speed up cell turnover rates. Simply put, the medication makes the dead skin cells shed more quickly and effectively than they would on their own.

Tretinoin medications also help the plugs of dead skin cells and oil trapped within the pore become less sticky. When all of that "gunk," technically called comedones, isn't hanging around in your pores anymore, you won't get as many breakouts.

Retin-A and Retin-A Micro are used to treat mild to moderately severe acne vulgaris. They both help reduce non-inflamed breakouts, like blackheads, as well as inflamed pimples.

Topical retinoids like Retin-A and Retin-A Micro can be used by tweens, teens, and adults. In fact, many adults without acne use Retin-A because it's great for softening lines and wrinkles and giving the skin an overall younger look.

Retin-A and Retin-A Micro are Formulated Differently

Retin-A and Retin-A Micro are basically different versions of the same medication. They work in the same way, they're used to treat the same skin problems, and they contain the same active ingredient. The main difference between Retin-A Micro and Retin-A is how they are formulated.

Retin-A comes in cream, gel, and liquid forms. No matter which form you use, when Retin-A is applied to the skin the full potency of the medication is delivered immediately. It has a risk of skin irritation, so getting the full dose immediately can influence whether you experience this side effect. 

Retin-A Micro only comes in gel form. The "micro" in the name stands for microsphere. That's where Retin-A Micro has an edge on Retin-A. These microspheres release the medication more slowly, over time. This does two things:

  • It allows the medication to be effective on your skin for longer periods of time.
  • The medication is less irritating to the skin than Retin-A because you're not getting more active ingredient released on your skin at one time.

Another difference between the two medications is that you must wait 20 to 30 minutes after cleansing before applying Retin-A.

With Retin-A Micro, waiting isn't an issue. You can use it immediately after washing your face.

Which Medication is Right for Your Skin?

Because you can only get Retin-A and Retin-A Micro by prescription, you'll have to consult your dermatologist. During your appointment, your dermatologist will take a look at your skin and your medical history. Then, your dermatologist can help you develop an effective acne treatment plan. If you're interested in trying either Retin-A or Retin-A Micro, ask your dermatologist about them. Your derm will help you choose between the two, or will let you know if another acne treatment is more appropriate.

All in all, both Retin-A and Retin-A Micro are good options for treating acne. Retin-A Micro should have less risk of being irritating and should be less drying than Retin-A. It may be slightly more effective, in part because you will be more likely to use it if it isn't as irritating.

The biggest downside is that Retin-A Micro is much more expensive than Retin-A. This may or may not be a factor for you, depending on your insurance. Estimate your out-of-pocket costs for each.

A Word From Verywell

There are benefits and drawbacks to both products, so choosing between the two can seem overwhelming. But remember, you don't have to make the decision on your own, your dermatologist is there to help.


Kircik LH. Evaluating tretinoin formulations in the Treatment of Acne. Journal of Drugs in Dermatology. 2014 Apr;13(4):466-70.

Kircik LH. Microsphere Technology: Hype or Help? J Clin Aesthet Dermatol. 2011 May; 4(5): 27-31.

Retin-A Micro Prescribing Information. Ortho Dermatologics.

Tretinoin Topical. MedlinePlus U.S. National Library of Medicine & National Institutes of Health. https://medlineplus.gov/druginfo/meds/a682437.html.

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