Dymista Spray Treats Seasonal Allergies, Nasal Congestion

Combination Nasal Spray Improves Allergies and May Relieve Snoring


The pharmaceutical drug Dymista (known also by its generic name of azelastine/fluticasone propionate nasal) is a prescription spray delivered through the nose to relieve symptoms of seasonal allergies and nasal congestion. It may be useful to reduce snoring and as an adjunctive treatment for obstructive sleep apnea. Learn more about how it works, if you should use it, and the potential side effects.

Uses of Dymista

Dymista is a combination prescription medication, containing the main ingredients found in two other prescription nasal sprays: Astelin and Flonase. It can relieve nasal congestion, a runny nose, and difficulty breathing through the nose caused by seasonal allergies. As these difficulties breathing during sleep may result in snoring, upper airway resistance syndrome, or even obstructive sleep apnea, it may be helpful in these scenarios. It may also help to reduce the swelling of tissues in the nose called turbinates.

How Does Dymista Work?

Dymista is a corticosteroid nasal spray. It decreases the inflammation of tissues lining the nose. The exact way it works is not fully known. In general, medications like it act to reduce chemicals in the body called cytokines. Cytokines are important to the immune system and they may be present and cause inflammation as a result of allergen exposure.

In addition, it may block histamines, which are also associated with seasonal allergies such as hay fever.

Who Should Not Use Dymista?

There are a few situations in which Dymista should be used with caution or not at all. It should be avoided if you have an unhealed ulcer on the nasal septum or other wound in the nose.

Caution is advised with the use of alcohol or other medications that may depress consciousness. Those with eye conditions such as glaucoma and cataracts should be cautious in using it. Untreated infections, including tuberculosis, may be affected by taking Dymista. In addition, children and adolescents should be monitored for effects on growth. The safety of Dymista use during pregnancy and breastfeeding is not fully known and caution is advised. Dymista has the potential to interact with other medications, so it's recommended that you review all drugs that you're taking with your doctor if you are using, or plan to use, Dymista.

What Are Common Side Effects of Dymista?

As with the use of any prescription medication, there exists the potential for side effects with the use of Dymista. Although you would not be expected to experience most side effects – and would likely not experience any of them – some of the more common side effects that occur with the use of Dymista include:

  • Headache
  • Sleepiness
  • Pain
  • Cold-like symptoms
  • Nosebleed (epistaxis)
  • Nasal ulcer
  • Nasal septum perforation (hole)
  • Candida infection (yeast in nose or mouth)
  • Altered sense of taste
  • Bitter taste
  • Diarrhea

What Are Potential Serious Reactions of Dymista?

With the use of any drug, there are also risks of serious side effects. These would be expected to occur more rarely, and often only with long-term medication use, but may include:

  • Anaphylaxis (allergic reaction such as throat swelling and difficulties breathing)
  • Glaucoma
  • Cataracts
  • Abnormal cortisol levels
  • Suppression of the adrenal glands
  • Growth restriction in children
  • Suppression of the immune system

What Safety Precautions Need to Be Taken With Dymista?

As noted above, there are some people who should use Dymista with caution, or not at all. It is important to have a nasal exam with more than 2 months of use. The height of children and adolescents should be monitored to ensure continued normal growth in long-term use. With a history of eye problems, a regular ophthalmic examination is important. If you are pregnant or nursing, you should discuss the safety and risks versus benefits with your physician.

If you have any difficulties with the use of Dymista, you should be in close contact with your prescribing health provider.


“Dymista.” Epocrates Rx Pro. Version 14.11.2, 2012. Epocrates, Inc. San Mateo, California.

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