How Long Does Naltrexone Stay in Your System?

Detection Timetable Depends on Many Variables

Revia Label
Naltrexone Hydrocholoride Tablets. Tieva

Trying to determine exactly how long naltrexone is detectable in the body depends on many variables, including what form of the medication you are taking - oral pill form or once-a-month injection - and which kind drug test is being used.

Naltrexone - marketed as ReVia, Vivitrol, and Depade - can be detected for a shorter time with some tests, but can be "visible" for up to three months in other tests.

The timetable for detecting naltrexone in the system is also dependent upon each individual's metabolism, body mass, age, hydration level, physical activity, health conditions and other factors, making it almost impossible to determine an exact time naltrexone will show up on a drug test.

The following is an estimated range of times, or detection windows, during which the pill form of naltrexone, which is taken orally, can be detected by various testing methods:

How Long Does Naltrexone Stay in the Urine?

Naltrexone can be detected in the urine for 4-6 hours.

How Long Can Naltrexone Be Detected in Blood?

A blood test can detect Naltrexone for up to 24 hours.

How Long Can a Saliva Test Detect Naltrexone?

A saliva test can detect Naltrexone for up to 1 day

How Long Can a Hair Test Detect Naltrexone?

Naltrexone, like many other drugs, can be detected with a hair follicle drug test for up to 90 days.

Avoiding a Naltrexone Overdose

Naltrexone is in a class of medications called opiate antagonists. It works by decreasing the craving for alcohol and blocking the effects of opiate medications and illicit opioid drugs. It is used to help people who have stopped drinking alcohol and using street drugs continue to avoid drinking or using drugs, along with counseling and social support.

To avoid a possible accidental overdose of Naltrexone, do not take more or less of it or take it more often than prescribed.

Symptoms of an overdose of Naltrexone include:

If you suspect someone has taken an overdose of Naltrexone, call the poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call 9-1-1.


Always Test Clean. "What Are Drug Detection Times?" Drug Test Facts Accessed December 2015

American Association for Clinical Chemistry "Drugs of Abuse Testing." Lab Tests Online. Revised 2 January 2013.

LabCorp, Inc. "Drugs of Abuse Reference Guide." Accessed March 2013.

OHS Health & Safety Services. "How long do drugs stay in your system?." Accessed March 2013.

National Institue on Drug Abuse. "Naltrexone." Drugs, Herbs and Supplements February 2009

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