How Long Does Oxycodone Stay in Your System?

Detection Timetable Depends on Many Variables

Blood Test Vial
Different Tests Used to Detect Drugs. © Getty Images

Determining exactly how long oxycodone is detectable in the body depends on many variables, including which kind drug test is being used. Oxycodone - also known as Percodan, Percocet, Tylox, OxyContin, Roxicodone, Roxicet, Endocet, Oxies, O.C., hillbilly heroin - can be detected for a shorter time with some tests, but can be "visible" for up to three months in other tests.

The timetable for detecting oxycodone in the system is also dependent upon each individual's metabolism, body mass, age, hydration level, physical activity, health conditions and other factors, making it almost impossible to determine an exact time oxycodone will show up on a drug test.

The following is an estimated range of times, or detection windows, during which oxycodone can be detected by various testing methods:

How Long Does Oxycodone Show Up in Urine?

Oxycodone is detectable in a urine test for 3-4 days.

How Long Does Oxycodone Stay in the Blood?

A blood test will detect Oxycodone for up to 24 hours.

How Long Will Oxycodone Show Up in a Saliva Test?

A saliva test will detect Oxycodone from 1-4 days.

How Long Does Oxycodone Remain in Hair?

Oxycodone, like many other drugs, can be detected with a hair follicle drug test for up to 90 days.

How Is Oxycodone Metabolized?

Oxycodone is metabolized by the cytochrome P450 enzyme system in the liver. Oxycodone is extensively metabolized by multiple metabolic pathways to produce noroxycodone, oxymorphone and noroxymorphone, which are subsequently glucuronidated.

How Is Oxycodone Eliminated From the Body?

Oxycodone is primarily eliminated from the body via the kidneys through urine and to a lesser extent sweat.

The half-life of oxycodone is about 3.2 hours, while the half-life for the time-released version (OxyContin) is about 4.5 hours.

Sources:

Always Test Clean. "What Are Drug Detection Times?" Drug Test Facts Accessed June 2015

American Association for Clinical Chemistry "Drugs of Abuse Testing." Lab Tests Online. Revised 2 January 2013.

LabCorp, Inc. "Drugs of Abuse Reference Guide." Accessed March 2013.

Smith, HS "Opioid Metabolism." Mayo Clinic Proceedings July 2009

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