How Long Does Peyote Stay in Your System?

Detection Timetable Depends on Many Variables

Peyote Plant
Buttons on a Peyote Catus. DEA

Estimating how long peyote is detectable in the body depends on many variables, including which kind drug test is being used. Peyote - also known as mesc, peyote buttons, broken, dead - can be detected for a shorter time with some tests, but can be "visible" for up to three months in other tests.

The timetable for detecting peyote in the system is also dependent upon each individual's metabolism, body mass, age, hydration level, physical activity, health conditions and other factors, making it almost impossible to determine an exact time peyote will show up on a drug test.

The following is an estimated range of times, or detection windows, during which peyote can be detected by various testing methods:

How Long Does Peyote Stay in the Urine?

Peyote can be detected in the urine for 2-3 days

How Long Can Peyote Be Detected in Blood?

There is some data available that indicates Peyote can be detected in the blood for up to 24 hours.

How Long Can a Saliva Test Detect Peyote?

A saliva test can detect Peyote for up to 1-10 days

How Long Can a Hair Test Detect Peyote?

Peyote, like many other drugs, can be detected with a hair follicle drug test for up to 90 days.

Preventing Peyote Side-Effects

Peyote is a small cactus for which the principal active ingredient is mescaline. Mescaline can also be manmade through chemical synthesis. The dried peyote buttons are usually dried and then chewed or made into a liquid or tea for consumption.

The amount of mescaline needed to produce hallucinations is very small - usually 0.3 to 0.5 grams.

The effects last about 12 hours, but it remains in the system for a much longer time.

The physical effects of peyote can be similar to those of LSD, including:

Long-Term Effects of Peyote

According to the NIDA, repeated or long-term use of peyote can cause some users to develop persistent psychosis with symptoms that can include:

  • Visual disturbances
  • Disorganized thinking
  • Paranoia
  • Mood disturbances

Hallucinogen Persisting Perception Disorder

Repeated use of peyote may also contribute to the development in some users of hallucinogen persisting perception disorder (HPPD), otherwise known as "flashbacks." With HPPD, peyote users report seeing "halos" around people and objects or "trails" following moving objects.

Some of the symptoms of HPPD are sometimes mistaken for neurological disorders such as stroke or brain tumor.

Both persistent psychosis and HPPD are rare among peyote users, but they can occur without warning and have been reported even after a single exposure to peyote. Generally, these symptoms occur in individuals with a history of psychiatric problems.


Always Test Clean. "What Are Drug Detection Times?" Drug Test Facts Accessed December 2015

American Association for Clinical Chemistry "Drugs of Abuse Testing." Lab Tests Online. Revised 2 January 2013.

LabCorp, Inc. "Drugs of Abuse Reference Guide." Updated May 2016.

OHS Health & Safety Services. "How long do drugs stay in your system?." Accessed March 2013.

National Institute on Drug Abuse. "Hallucinogens - LSD, Peyote, Psilocybin, and PCP." Drug Facts December 2014

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