How Long Does Ultram Stay in Your System?

Detection Timetable Depends on Many Variables

Vial of Blood
Blood Test Can Detect Heavy Drinking. © Getty Images

Determining exactly how long Ultram is detectable in the body depends on many variables, including which kind drug test is being used. Ultram - also known as Tramadol, Ultram, Ultracet, Tram cars - can be detected for a shorter time with some tests, but can be "visible" for up to three months in other tests.

The timetable for detecting Ultram in the system is also dependent upon each individual's metabolism, body mass, age, hydration level, physical activity, health conditions and other factors, making it almost impossible to determine an exact time Ultram will show up on a drug test.

The following is an estimated range of times, or detection windows, during which Ultram can be detected by various testing methods:

How Long Does Ultram Remain in Urine

Ultram can be detected in a urine test from 2-4 days.

How Long Does Ultram Stay in the Blood

A blood test can detect Ultram for approximately 6 hours.

How Long Can Ultram Be Detected in Saliva?

Ultram can be detected in a saliva test for 1-4 days.

How Long Can Ultram Be Detected in Hair?

Ultram, like many other drugs, can be detected with a hair follicle drug test for up to 90 days.

What Are the Dangers of Ultram Use?

Ultram is in a class of medications called opiate (narcotic) analgesics and therefore can be very addictive. If taken over a long period of time Ultram can create a physical dependence. Even when taken in prescribed amounts, Ultram can cause seizures after been used over a long period of time.

Also, because Ultram is an opioid painkiller, there is a chance of overdose, especially when combined with other central nervous system depressants or alcohol.

Side-Effects of Ultram

Even when taken as directed, Ultram, like other opioid painkillers, can cause serious side-effects, some of which can be severe:

  • Seizures
  • Hives
  • Rash
  • Blisters
  • Difficulty swallowing or breathing
  • Swelling of the eyes, face, throat, tongue, lips, hands, feet, ankles, or lower legs
  • Hoarseness
  • Agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination
  • Nausea, vomiting, loss of appetite, weakness, or dizziness
  • Inability to get or keep an erection
  • Irregular menstruation
  • Decreased sexual desire
  • Changes in heartbeat
  • Loss of consciousness

Symptoms of an Ultram Overdose

Symptoms of overdose may include the following:

Danger of Drug Interactions With Ultram

There is a long list of medications listed by the U.S. National Library of Medicine that might produce negative reactions when taken along with Ultram. Some of those medications include:

  • Anticoagulants such as Coumadin
  • Certain antifungal medications such as Nizoral, Lanoxin, E.E.S., E-Mycin, Erythrocin, Zyvox, Lithobid)
  • Medications for anxiety, mental illness, nausea, and pain
  • Certain medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig)
  • Medications for seizures, such as Equetro, Tegretol
  • MAO inhibitors, including Marplan, Nardil, Eldepryl, Zelapar, and Parnate
  • Muscle relaxants such as Flexeril, Phenergan, Rifadin, Rifamate, Rimactane
  • Sedatives; sleeping pills
  • Selective serotonin reuptake inhibitors (SSRIs) such as Celexa, Prozac, Sarafem, Luvox, Paxil, Pexeva, and Zoloft
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs) such as Pristiq, Cymbalta, and Effexor
  • Tranquilizers
  • Tricyclic antidepressants such as Anafranil, Norpramin, Silenor, Tofranil, Aventyl, Pamelor, Vivactil, and Surmontil.


American Association for Clinical Chemistry "Drugs of Abuse Testing." Lab Tests Online. Revised 2 January 2013.

LabCorp, Inc. "Drugs of Abuse Reference Guide." Accessed March 2013.

OHS Health & Safety Services. "How long do drugs stay in your system - including alcohol?." Accessed March 2013.

U.S. National Library of Medicine. "Tramadol." Drugs, Herbs, and Supplements October 2010