Intestinal Permeability Test

Healthy digestive system, artwork

An intestinal permeability test, also called a lactulose and mannitol test, is sometimes used in alternative medicine to assess the health of the small intestine lining. The test measures the ability of two sugar molecules, mannitol and lactulose, to pass through the lining of the small intestine. Ordinarily, mannitol is easily absorbed but lactulose is not. 

In alternative medicine, this assessment is sometimes suggested for the following conditions:

  • Malabsorption
  • Inflammatory bowel disease
  • Food allergies
  • Inflammatory joint disease

Typically, the person taking the test does an overnight fast, then drinks a mixture of lactulose and mannitol. He or she then collects urine samples over the six hours following ingestion of the beverage.  

Taking the Test

If you're experiencing any symptoms or are considering taking the test, make sure to consult your physician first. It's also important to note that self-treating a condition and avoiding or delaying standard care may have serious consequences.

Disclaimer: The information contained on this site is intended for educational purposes only and is not a substitute for advice, diagnosis or treatment by a licensed physician. It is not meant to cover all possible precautions, drug interactions, circumstances or adverse effects. You should seek prompt medical care for any health issues and consult your doctor before using alternative medicine or making a change to your regimen.

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