Levsin Frequently Asked Questions

This Drug May Be Given To Relax Smooth Muscle Tissue

Drugs
Levsin is a medication that may be used to treat irritable bowel syndrome (IBS). Image © ShutterWorx / E+ / Getty Images

Generic name: Hyoscyamine
Other brand name: Anaspaz

What is Levsin?

Levsin is classified as an anticholinergic-sedative and is a combination of two drugs: belladonna alkaloids and barbiturates. It is a medication prescribed by a physician in order to relax the muscles in the bladder and intestines as well as reduce stomach acid.

Why Is Levsin Prescribed?

Levsin may be used to treat irritable bowel syndrome (IBS), diverticulosis, and bladder spasms.

How Is Levsin Taken?

Levsin should be taken anywhere from 30 to 60 minutes before eating a meal. It should never be taken at the same time as antacids (such as Tums or Rolaids), because these medications can decrease the absorption of Levsin by the body.

What Do I Do If I Miss A Dose?

If you miss a dose, take it as soon as you remember. If your next dose should be taken soon, just take that dose. Don't double up, or take more than one dose at a time.

Who Should Not Take Levsin?

Before taking Levsin, tell your doctor if you have, or have ever had:

  • Asthma, emphysema, or chronic lung disease
  • Congestive heart failure
  • Down's syndrome
  • Glaucoma
  • Hypertension (high blood pressure)
  • Intestinal blockage
  • Kidney disease
  • Liver disease
  • Prostate enlargement (BPH)
  • Severe ulcerative colitis where bowel movements have stopped

What Are The Side Effects?

The most serious side effects from Levsin are confusion, blurred vision, and difficulty in urination, and decreased sweating.

If you experience these symptoms call your doctor immediately. Take care to drink enough water while taking this drug, particularly in hot weather or while exercising.

Other common side effects include headache, nausea, constipation, rash, and vomiting. See the Levsin Side Effects page for a complete list.

What Medications Can Levsin Interact With?

Levsin can interact with several different classes of drugs. For this reason, it is important for a physician prescribing this medication to know about all other drugs and supplements (even vitamins) that are being taken. This is especially true when taking any of the medications from the following list, because they may interact with the Levsin:

  • Antacids
  • Anticoagulants
  • Antidepressants
  • Antihistamines
  • Amantadine
  • Cardiac rhythm regulators
  • Cimetidine
  • Digoxin
  • Metoclopramide
  • Monoamine oxidase (MAO) inhibitors
  • Potassium chloride
  • Prednisone
  • Sedatives
  • Thiazide diuretics

Are There Any Food Interactions?

Consuming alcohol while taking Levsin could have a sedative effect and cause tiredness or sleepiness. People taking Levsin shouldn't drink alcohol for this reason. Take care to avoid alcohol from unexpected sources, such as over the counter cough suppressants or cold products (Nyquil, for example).

Levsin may also cause constipation in some people. A high fiber diet and drinking plenty of water should help to avoid the development of constipation.

Is Levsin Safe During Pregnancy?

The FDA has classified Levsin as a type C drug. The belladonna portion of Levsin has not been shown to cause any problems for pregnant women.

However, the barbiturate portion does increase the risk of birth defects and bleeding in newborns. Levsin does pass into breast milk and therefore could be taken up by a nursing infant. It's speculated that a single dose of Levsin in a breastfeeding mother might not be a cause for great concern, but it is known that infants are particularly sensitive to this type of drug. It's not known how Levsin may affect a nursing infant.

Levsin should only be used during pregnancy if clearly needed. Notify the prescribing doctor if you become pregnant while taking Levsin. The potential for serious side effects in an infant should be weighed against the usefulness of the medication to the mother.

Can Levsin Cause Any Sexual Side Effects?

Levsin is associated with impotence (erectile dysfunction) in men. Levsin may also suppress the production of breast milk in nursing mothers.

A Word From Verywell

Levsin is one of many different medications that are used to treat IBS. It may be helpful for some people with IBS, but there are precautions that should be used while taking it. Alcohol needs to be avoided while taken Levsin to avoid becoming very drowsy. Levsin should probably be avoided by pregnant women or breastfeeding mothers, but this is best discussed with physicians such as an obstetrician/gynecologist and pediatrician, and healthcare professionals such as a lactation consultant. 

Sources:

Alaven Pharmaceutical LLC. "Levsin/SLtablets (hyoscyamine sulfate tablets USP)." Feb 2008.

PDR LLC. "Hyoscyamine sulfate." PDR.net. 2017.

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