Low grade squamous intraepithelial lesion (LGSIL)

Low Grade Squamous Intraepitheliel Lesion

equipment for Pap smear
LGSIL is a medical term given to a level of cervical dysplasia and is detected through a Pap smear. SATURN STILLS/Science Photo Library/Getty Images

Low grade squamous intraepithelial lesion (LGSIL) is a medical term given to a level of cervical dysplasia and is detected through a Pap smear. An LGSIL result means that mild dysplasia, more than likely caused by the human papillomavirus, has been detected. It is the most common classification of cervical dysplasia, and in most cases, clears up on its own within two years.

What is a Pap Smear?

A Pap smear, also called a Pap test, is a procedure to test for cervical cancer in women.

 A Pap smear involves collecting cells from your cervix — the lower, narrow end of your uterus that's at the top of your vagina.

Management of LGSIL Pap Result

If LGSIL is found through a Pap smear, a colposcopy is then done to confirm results. A colposcopy is an in-office procedure that allows a doctor to examine the cervix more in-depth.

It is done by using a colposcope, a lighted microscope that magnifies the cervix. During the colposcopy, the doctor may also do a cervical biopsy, the removal of small pieces of cervical tissue. The tissue samples are then sent to a lab for further examination.

A colposcopy is performed in the doctor's office and normally takes less than an hour to perform. Results are available within two weeks, depending on the lab the doctor uses.

LGSIL Treatment

One of the most common methods to treating LGSIL is a "watch and wait" approach. Because low-grade dysplasia usually resolves itself, no medical treatment may be needed.

Colposcopies and biopsies may be done at regular intervals to monitor the dysplasia. If it progresses, treatment may be necessary.

Treatment to remove abnormal tissue includes:

  • Cryotherapy: Cryotherapy is a technique used to destroy abnormal tissue by freezing it. It is also called crysosurgery.
  • Conization: Also called a cone biopsy, conization removes a larger, cone-shaped sample of abnormal tissue.
  • Laser Therapy: During laser therapy, a tiny beam of light is used to destroy abnormal cells.


Mayo Clinic. Pap Smear. http://www.mayoclinic.org/tests-procedures/pap-smear/basics/why-its-done/prc-20013038

"National Cancer Institute Fact Sheet." The Pap Test: Questions and Answers. 12 FEB 2003. National Cancer Institute. 22 Oct 2006.

"National Cancer Institute Fact Sheet." Lasers in Cancer Treatment: Questions and Answers. 10 AUG 2004. National Cancer Institute. 22 Oct 2006.

"Cervical Cancer (PDQ®): Treatment." General Information About Cervical Cancer. 19 APR 2006. National Cancer Institute. 22 Oct 2006 .

"Tutorials." Colposcopy. 10 July 2004. National Library of Medicine. 22 Oct 2006.

Continue Reading