List of Approved HIV Antiretroviral Drugs

27 individual drug agents now available to treat HIV infection

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Triumeq (600mg Ziagen + 300mg Epivir + 50mg Tivicay). Courtesy ViiV Healthcare

Antiretroviral drugs are organized into five classes based on the stage of the HIV life cycle they are known to inhibit. Today, there are 27 individual agents (known as "drug molecules") and 12 fixed dosed combination (FDC) drugs comprised of two or more of different molecules. Seven of the FDCs can, in fact, be used as a single-pill, once-daily therapies, ensuring greater treatment adherence and ease of use.

Drug ClassBrand NameGeneric NameAdult DosingDietary Notes
Entry InhibitorsFuzeonenfuvirtide, T-2090mg (1 mL) injected twice dailyNone
 Selzentry, CelsentrimaravirocOne 150mg tablet twice daily, one 300mg tablet twice daily, or two 300mg tablets twice daily, depending on drug regimenNone
Pharmokinetic Enhancers (a.k.a. HIV Drug "Boosters")NorvirritonavirTechically a protease inhibitor, Norvir is used almost exclusively to "boost" the serum drug levels of other protease inhibitors (PIs); prescribers should consult with full prescribing information when co-administered with PIsTaken with or without food
 Tybostcobicistat150mg taken once daily; technically a CYP3A inhibitor, Tybost is used to "boost" the serum drug levels of a number of protease inhibitors (PIs)Taken with food
Integrase InhibitorsIsentressratelgravirOne 400mg tablet taken twice dailyTaken with or without food
 TivicaydolutegravirOne 50mg tablet daily for untreated patients; one 50mg tablet twice daily for treatment-experienced patients with resistance to IsentressTaken with or without food
 Vitektaelvitegravir85mg or 150mg tablet taken either once or twice daily, along with Norvir and another protease inhibitor; refer to dosing chart for specific dosagesTaken with food
Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTIs/NtRTIs)EmtrivaemtricitabineOne 100mg tablet taken once daily, or one 150mg tablet taken twice dailyTaken with or without food
 EpivirlamivudineOne 300mg tablet taken once daily, or one 150mg tablet taken twice dailyTaken with or without food
 RetrovirAZT, zidovudineOne 300mg tablet taken twice dailyFood may ease stomach discomfort
 Videx ECdidanosine, ddIOne 400mg capsule taken once daily; or one 200mg capsule taken once daily for patients under 133 lbs (60kg)Taken on empty stomach
 VireadtenofovirOne 300mg tablet taken once dailyTaken with or without food
 ZeritstavudineOne 40mg capsule taken 12 hourly for patients 133 lb (60kg) and over; or one 30mg capsule taken 12 hourly for patients less than 133 lbs (60kg)Taken with or without food
 ZiagenabacavirTwo 300mg tablets taken once daily, or one 300mg tablet taken twice dailyTaken with or without food
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)EdurantrilpivirineOne 25mg tablet taken once dailyTaken with a meal
 IntelenceetravirineOne 200mg tablet taken twice dailyTaken with a meal
 RescriptordelavirdineTwo 200mg tablets taken three times dailyTaken with or without food
 Sustiva, StocrinefavirenzOne 600mg tablet taken once dailyRecommend empty stomach
 Viramune XRnevirapineInduction dose of one 200mg Viramune tablet daily for 14 days, then one 100mg Viramune XR tablet dailyTaken with or without food
Protease Inhibitors (PIs)AptivustipranavirTwo 250mg capsules taken with 200mg Norvir twice dailyBest taken with a meal
 CrixivanindinavirTwo 400mg capsules taken with either 100mg or 200mg Norvir twice daily (preferred), or two 400mg capsules taken every 8 hoursWith Norvir, take with or without food; without Norvir, take on empty stomach
 InvirasesaquinavirTwo 500mg tablets taken with 100mg Norvir twice dailyBest taken with food or within 2 hours of eating
 Kaletra, Aluvia200 mg lopinavir + 50mg Norvir (Note - lopinavir is only available as part of Kaletra/Aluvia)Two tablets twice daily; four tablets once daily is acceptable for untreated patients or patients with less than 3 mutations associated with lopinavir resistanceTaken with or without food
 Lexiva, TelzirfosamprenavirTwo 700mg tablets taken twice daily; or two 700mg tablets taken with 100mg 100mg Norvir once daily; or one 700mg tablet taken with 100mg Norvir twice daily for patients with previous PI failureTaken with or without food
 PrezistadarunavirOne 800mg tablet (or two 400mg tablets) taken with 100mg Norvir once daily; or one 600mg tablet taken with 100mg Norvir twice daily for patients with known levels of Prezista- associated resistanceTaken with food
 ReyatazatazanavirTwo 200mg capsules taken once daily, or one 300mg (or two 150mg) capsules taken with 100mg Norvir once dailyTaken with light meal
 ViraceptnelfinavirTwo 625mg tablets taken twice daily, or five 250mg tablets taken twice daily, or three 250mg tablets taken three times dailyTaken with a meal or light snack
Fixed Dose Combination (FDC) DrugsCombivir300mg Retrovir + 150mg EpivirOne tablet taken twice dailyFood may ease stomach discomfort
 Epzicom, Kivexa600mg Ziagen + 300mg EpivirOne tablet taken once dailyTaken with or without food
 Evotaz300mg Reyataz + 150mg TybostOne tablet taken once dailyTaken with food
 Prezcobix800mg Prezista + 150mg TybostOne tablet taken once dailyTaken with food
 Truvada300mg Viread + 200mg EmtrivaOne tablet taken once dailyTaken with or without food
All-in-One Fixed Dose Combination (FDC) DrugsAtripla600mg Sustiva + 300mg Viread + 200mg EmtrivaOne tablet taken once daily; no other antiretroviral agent neededBest on empty stomach
 Complera25mg Edurant + 300mg Viread + 200mg EmtrivaOne tablet taken once daily; no other antiretroviral agent neededBest taken with food
 Genvoya150mg Vitekta + 150mg Tybost+ 10mg tenofovir alafenamide + 200mg EmtrivaOne tablet taken once daily; no other antiretroviral agent neededTaken with food
 Odefsey25mg Edurant + 25mg tenofovir alafenamide + 200mg EmtrivaOne tablet taken once daily; no other antiretroviral agent neededTaken with food
 Stribild150mg Vitekta + 150mg Tybost+ 300mg Viread + 200mg EmtrivaOne tablet taken once daily; no other antiretroviral agent neededTaken with food
 Triumeq600mg Ziagen + 300mg Epivir + 50mg TivicayOne tablet once daily; no other antiretroviral agent needed  Taken with or without food
 Trizivir300mg Ziagen + 300mg Retrovir + 150mg EpivirOne tablet taken twice daily; can be prescribed alone or in combination with other antiretroviral agentsBest taken with food

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