Myeloma Signs and Symptoms

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Signs and Symptoms of Myeloma:

The signs and symptoms of myeloma are related to the effects from over-production of plasma cells in the bone marrow crowding out other types of cell production, bone damage from myeloma cell invasion, and increased immunoglobulin proteins accumulating throughout the body.

Signs and symptoms of myeloma may include:

  • Bone pain or fractures, especially in the spine, breastbone and pelvis
  • Tiredness that is not relieved with a good sleep or nap
  • Dizziness or shortness of breath from decreased red blood cell production in the bone marrow
  • Infections that you can’t seem to fight off from decreased white cell production in the bone marrow
  • Excessive thirst, frequent urination or nausea caused by too much calcium being released into the bloodstream from bone breakdown
  • Kidney problems from trying to filter extra calcium and light chain portions of immunoglobulins from the blood

These can also be symptoms of other conditions. If you are concerned about any health issues you may be experiencing, you should seek help from a medical professional.


Kyle, Robert and Rajkumar, S. Vincent "Multiple Myeloma" Blood 15 March 2008 111:2962-2972.

Lin, Pei "Plasma Cell Myeloma" Hematology/ Oncology Clinics of North America 2009 23:709-727.

Nau, Konrad and Lewis, William "Multiple Myeloma: Diagnosis and Treatment" American Family Physician 1 October 2008 78:853-859.

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