Treating Acne with Oral Erythromycin

Oral erythromycin blister pack of tablets
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Oral erythromycin is an antibiotic used to treat moderate to severe inflammatory acne, or acne that isn’t getting better with other treatments.  Erythromycin is also used topically to treat acne.

Besides acne, erythromycin is used to treat a wide variety of conditions, from ear infections to rosacea. It’s a prescription medication and there is no over-the-counter alternative.

How It Works

Erythromycin works to improve acne by reducing the amount of acne-causing bacteria, called propionibacteria acnes, on the skin.

  It also lessens inflammation and redness that's caused by breakouts.

Oral erythromycin is not really meant to be used as a long-term acne treatment. Ideally, you'll take it for only a few months or just until your acne starts to get better.   Then you'll stop using the erythromycin and continue acne treatment with another medication that's better suited to long-term use, like a topical combination acne medication, oral contraceptives (for women), etc.  Think of oral erythromycin as a jump start to get inflammation under control.

Erythromycin Isn't the First Antibiotic Choice for Acne

Erythromycin has been used for years to treat acne, although newer antibiotics are the more popular choice today.  It simply isn't the most effective antibiotic treatment for acne.

Some of the other oral antibiotics that are used more often to treat acne are:

    Erythromycin is still the best antibiotic option for pregnant or breastfeeding moms, though. It also can be used by younger children because, unlike some of the other oral antibiotics, it won’t cause tooth discoloration.

    Antibiotic Resistance and Oral Erythromycin

    You’ve probably heard about the growing problem of bacterial resistance caused by the overuse of antibiotics.

    Because of this, some people find their acne doesn’t respond well to erythromycin treatment.

    To help combat antibiotic resistance, oral erythromycin shouldn't be the only treatment you're using to clear your acne.  It will work best if it's combined with another acne treatment medication.  Topical retinoids and benzoyl peroxide work really well when used alongside oral antibiotics.

    Possible Side Effects of Oral Erythromycin

    All acne medications have them, and oral erythromycin is no different.  Your dermatologist will tell you all about possible side effects before you start your treatment, but these are the most common:

    • Upset stomach
    • Nausea and vomiting
    • Diarrhea
    • Vaginal yeast infections or oral thrush

    If you develop severe stomach pain or severe diarrhea, let your doctor know right away.  Is erythromycin upsetting your stomach? Taking your erythromycin with food can help.

    Oral antibiotics work best when there is a steady amount of the medication in the body. Do your best to take your medication at regular times and try not to skip doses.

    Make sure you take the entire course prescribed, even if your acne clears up. Tell your dermatologist if your acne isn’t improving at all, or if it gets better for a while but then returns.


    Dreno B, Thiboutot D, Gollnick H, Bettoli V, et. al.  "Antibiotic stewardship in dermatology: limiting antibiotic use in acne."  Eur J Dermatol.  2014 May-Jun;24(3):330-4.

    Pugashetti R, Shinkai K.  "Treatment of acne vulgaris in pregnant patients."  2013 Jul-Aug; 26(4):302-11.

    Whitney KM, Ditre CM.  "Management strategies for acne vulgaris."  Clin Cosmet Investig Dermatol.  2011;4:41-53.

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