What is the Meaning of Partial Response (PR)?

What Does a Partial Remission Mean with Leukemias and Lymphomas?

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Definition: Partial Response (PR)

After treatment completion, an individual is generally assessed for response after a period of time to allow maximal regression of the tumor. At the end of that period if there is some disease remaining but a reduction of disease by 30% or more on clinical examination or x-rays and scans – it is called partial response (or partial regression).

What Does a Partial Response Mean?

Partial response (PR) implies that further treatment will probably be required to attempt a cure.

In some slow growing tumors (including low grade lymphomas) no further treatment may be immediately necessary till the disease starts increasing in size again.

Understanding Terms Describing Cancer Treatment

There are so many terms used to describe cancer treatment that it gets terribly confusing.  Thankfully many of these mean about the same thing.  Some of these include:

  • Complete response - This means that a cancer has responded to treatment and no evidence of the cancer can be seen on imaging studies.
  • Complete remission - This means the same things as a complete response.
  • Partial response - Defined above
  • Partial remission means the same things as a partial response
  • NED  (No evidence of disease) means exactly that, and can be the same as a complete response or a complete remission.  Imaging studies are "normal" but that doesn't mean a cancer is gone, just that no evidence can be found on imaging studies that we currently have.
  • Progressive disease - The term progressive disease, or PD, means that a cancer has grown in size (or spread) by at least 20%
  • Stable disease - This means that a tumor has essentially not changed.  Stable disease could still mean that a cancer has responded, for example, if a cancer would have been expected to get worse but has stayed the same.
  • Recurrence - This means that a cancer has reappeared after a period of being in remission or being NED.
  • Relapse - This means the same thing as recurrence.

Plans after a Partial Response

As noted above, what happens after a partial response is largely dependent upon the type of cancer you have.  For the same reason, a partial response could be particularly good or particularly bad - it all depends not only on your specific cancer, but on the molecular profile of your specific cancer.  If you are searching for information on your cancer keep this in mind.  Numbers and statistics online do not take into account the tremendous variations between people, even those with the same type of cancer.  In addition, what you read online will often refer to statistics.  Statistics are numbers not people and are averages.  Very few people are "average."  And statistics are put together using data from how people with your cancer responded in the past to treatment.  These numbers do not take into account any new treatments since the time the data was recorded, so they may not be relevant to you.

Recurrence of Leukemia or Lymphoma

We are talking about partial response, but in the back of many of our minds is the fear of recurrence.  How can you cope with the fear of recurrence or the fear of progression? What happens when leukemia or lymphoma recur? Many people find it helpful to talk about the elephant in the room - open up and expose these fears.  Sometimes talking to a counselor is helpful if you catch yourself worrying.  Thankfully we live at a time when survival rates for many cancers are improving, and new treatments are being approved more rapidly than ever. Clinical trials are in progress not only for treatments we hope will improve survival, but for treatments with fewer side effects than in the past.

Also Known As: PR

Sources:

National Cancer Institute. Imaging Response Criteria. Accessed 02/26/16. http://imaging.cancer.gov/clinicaltrials/imaging

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