Can Pepto-Bismol or Kaopectate Turn Your Stool Black?

This Common Over-the-Counter Medicine Has a Surprising Side Effect

Girl Taking Medicine
The active ingredient in Pepto Bismol can cause a change in your stools.. Steven Puetzer/The Image Bank/Getty Images

Have you ever had stomach upset and then taken some Pepto-Bismol or Kaopectate? Maybe you felt better, but that day or the day after, something really weird happened. The next time you had a bowel movement, your  stool was black or even maybe it was even green. Taking these medications can have this effect. It is caused by the active ingredient  - bismuth subsalicylate.

How Bismuth Subsalicylate Works

Pepto-Bismol and Kaopectate (which are two of the well-known brand names, there are also generics or store brands the have similar ingredients) can be found in many drug stores.

These medications are often used for upset stomach, such as after eating too much, or for mild stomach discomfort. They're not usually prescribed for chronic conditions, or for ongoing digestive complaints. People who find themselves taking over-the-counter medications to manage digestive upset for longer than a few days should contact a physician.

Bismuth subsalicylate is known as an antidiarrheal drug. It has several effects on the digestive system: it can calm inflammation and reduce the amount of water going into the bowel. It also has antibacterial properties, and may work to inhibit certain organisms that cause diarrhea and other gastrointestinal symptoms. 

A small amount of a substance called sulfur is present in saliva and the gastrointestinal tract. Sulfur interacts with bismuth, the active ingredient in Pepto-Bismol. The result is a new substance called bismuth sulfide, which causes the stool to turn black.

Should You Worry About This Change in Stool Color?

The black or green stool after taking bismuth subsalicylate can last for several days, but it is harmless. This change in stool color is not a cause for concern unless you have stopped taking the bismuth subsalicylate and the unusual stool color persists.

What to Do if the Color Change Continues

If the black or green color in your stool does not stop a few days after the medicine is stopped, there could be something else going on. Black stool can happen for a variety of other reasons, including taking iron supplements and eating certain foods (like black sandwich cookies). But when it can not be traced to a food or a supplement, a doctor should be consulted because black, tarry stools could contain blood. Blood in the stool is always a serious concern, and will need evaluation.

Green stool is also common, especially after eating green or purple foods, However, green stool that continues for a longer time could be because of a medical problem. When stool moves through the body too quickly, it doesn't get a chance to be changed to brown, and it stays green.

Black or green stools that are accompanied by diarrhea, vomiting, abdominal pain or other symptoms, should prompt you to call your physician. Even if you think your stool changed color because of the bismuth subsalicylate, if you have these other symptoms too, you should seek medical care.


American Society of Health-System Pharmacists, Inc. "Bismuth Subsalicylate." MedlinePlus. 1 Feb 2011. 25 Nov 2015.

Pitz AM, Park GW, Lee D, Boissy YL, Vinjé J. "Antimicrobial activity of bismuth subsalicylate on Clostridium difficile, Escherichia coli O157:H7, norovirus, and other common enteric pathogens." Gut Microbes. 2015;6:93-100. 25 Nov 2015.

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