Can Rheumatoid Arthritis Affect the Spine?

Back pain is more commonly associated with osteoarthritis

Cervical spine
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If you have rheumatoid arthritis, it seems natural to blame all of your pain on the disease. After all, it is a chronic disease and symmetric joint pain is the primary symptom. But, what if you develop back pain or pain along the spine? Is that likely due to your rheumatoid arthritis?

Cervical Versus Lumbar Involvement of the Spine

Rheumatoid arthritis that affects the spine can cause neck pain, back pain, and there can be radiculopathy (pain that radiates to the legs or arms) due to compression of the nerves within the spinal cord or the nerve roots.

When rheumatoid arthritis is the source of back pain, it is more common for the cervical spine (neck region) to be affected rather than the thoracolumbar spine or sacroiliac joints. Cervical spine involvement with rheumatoid arthritis usually occurs with advanced disease.

It is the upper cervical spine that is typically involved in rheumatoid arthritis. Laxity of the ligaments that support the first and second cervical vertebrae (C1 and C2) can lead to instability at that level of the spine. Patients with rheumatoid arthritis should be routinely evaluated for symptoms of subluxation (partial dislocation) in the cervical spine. If subluxation causes compression of the spinal cord, there may be signs of long tract involvement (the upper motor neurons), including hyperreflexia (over-responsive reflexes).

There are two possible mechanisms that explain involvement of the intervertebral joints of the cervical spine in rheumatoid arthritis:

  • extension of the inflammatory process from adjacent neurocentral joints into the discovertebral area (the interface between the disc and vertebral body).
  • chronic cervical instability initiated by apophyseal (facet) joint destruction, leading to vertebral malalignment or subluxation, which may cause microfractures of the vertebral endplates, disc herniation, or degeneration of disc cartilage.

    Involvement of the facet joints of the lumbar spine and discitis have been attributed to rheumatoid arthritis on occasion, mostly following imaging and post-mortem studies. In clinical practice, before rheumatoid involvement of the lumbar spine can be diagnosed, common and serious causes of back pain (e.g., vertebral compression fractures) must be ruled out .

    Spine Involvement Associated With Rheumatoid Arthritis

    Symptoms that are usually associated with rheumatoid arthritis in the spine and that would be noticeable to the patient include:

    • palpation of the affected area of the spine causes tenderness
    • stiffness in the affected area of the spine
    • crepitus, especially in the neck region
    • headaches can occur with cervical rheumatoid arthritis
    • pain that radiates down one or both arms, indicative of cervical spinal root involvement (cervical radiculopathy)
    • pain that radiates down one or both legs, indicative of lumbar nerve root involvement (lumbar radiculopathy)
    • difficulty walking which is a sign of increased pressure on the spinal cord
    • tingling, weakness of arms or legs, changes to balance and coordination which may be signs of spinal cord involvement
    • a problem with bowel or bladder control (e.g., incontinence, inability to urinate, or inability to control the bowels) may be a sign of spinal cord involvement. This requires immediate medical attention

    If rheumatoid arthritis causes destruction of the facet joints in the spine, a condition known as spondylolisthesis may develop. With spondylolisthesis, an upper vertebra slides forward onto the top of the next adjacent lower vertebra. The slipped vertebra can put extra pressure on the spinal cord or the nerve roots where they exit the spine and cause some of the aforementioned problems associated with pressure on the spinal cord.


    Clinical manifestations of rheumatoid arthritis. UpToDate. Venables and Maini. Reviewed February 2016.

    Cervical subluxation in rheumatoid arthritis. UpToDate. Schur and Currier. Reviewed February 2016.

    Arthritis and Diseases That Affect the Back. The Arthritis Foundation. Accessed March 12, 2016.

    Rheumatoid Arthritis in the Spine. Peter F. Ullrich, Jr. MD. Updated 07/28/2011.

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