SNRI Serotonin-Norepinephrine Reuptake Inhibitor

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Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) are a type of antidepressant drug. They're often used to treat fibromyalgia and sometimes chronic fatigue syndrome because these conditions have common underlying physiology with depression -- specifically, neurotransmitter dysregulation.

Normally, the neurotransmitters serotonin and norepinephrine are released by a nerve cell, then reabsorbed back into the same cell.

The re-absorption is called "reuptake." SNRIs slow down reuptake, which makes the neurotransmitters available to your brain for a longer period of time.

Studies show that some people with fibromyalgia and chronic fatigue syndrome have low levels of serotonin and norepinephrine. Studies show that SNRIs may help ease some symptoms of fibromyalgia and may be helpful for chronic fatigue syndrome as well.

Examples of SNRIs include:

Also see:


Arnold LM, et al. The clinical journal of pain. 2009 Jul-Aug;25(6):461-8. Comparisons of the efficacy and safety of duloxetine for the treatment of fibromyalgia in patients with versus without major depressive disorder.

Arreola R, et al. Journal of immunology research. 2015;2015:354957. Immunomodulatory effects mediated by serotonin.

Derry S, et al. Cochrane database of systematic reviews. 2012 Mar 14;3:CD008244. Milnacipran for neuropathic pain and fibromyalgia in adults.

Goldstein, J. Alasbimn Journal2(7): April 2000. AJ07-5. "The Pathophysiology and Treatment of Chronic Fatigue Syndrome and Other Neurosomatic Disorders: Cognitive Therapy in a Pill."

Jensen KB, et al. The journal of pain. 2014 Dec;15(12):1328-37. Segregating the cerebral mechanisms of antidepressants and placebo in fibromyalgia.

Smith AK, et al. Psychoneuroendocrinology. 2008 Feb;33(2):188-97. Genetic evaluation of the serotonergic system in chronic fatigue syndrome.

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