Stroke, Obesity, and Diabetes Increasing Among Millennials

New research points at disturbing new trend

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During the past 20 years, the number of strokes has decreased. However, this trend applies to older adults. With respect to younger adults, including millennials, there’s been an increase in the number of strokes. This increase is likely rooted in an increase in other risk factors among younger people, including obesity, diabetes, and hypertension.

Stroke

In a 2017 article published in JAMA Neurology, George and co-authors examined the increased frequency of acute ischemic stroke among young people.

The researchers analyzed 362,339 hospitalizations from between 2003 and 2004 and 421,815 hospitalizations from between 2011 and 2012 to determine the incidence of acute stroke. They also used data from between 2003 and 2012 to determine the prevalence of five cardiovascular risk factors that predispose to acute stroke: hypertension, diabetes, lipid disorders, obesity, and tobacco use.

George and colleagues discovered that rates of hospitalizations due to acute ischemic stroke increased by more than 50 percent for men and women between 18 and 34. More specifically, for men, between 2003 and 2012, there was an increase from 11.2 to 18.0 acute strokes per 10,000 hospitalizations. For women, there was an increase from 3.8 to 5.8 acute strokes per 10,000 hospitalizations.

Going back even further, from between 1995 and 1996, the rates of stroke have almost doubled for men aged between 18 and 34.

Here are some other findings from the study regarding cardiovascular risk factors for people aged between 18 and 64 who were hospitalized for acute ischemic stroke between 2003 and 2012:

  • Rates of hypertension increased between 4 percent and 11 percent.
  • Rates of lipid disorder (i.e., hypercholesterolemia or high cholesterol) increased between 12 percent and 21 percent.
  • Rates of diabetes increased between 4 percent and 7 percent.
  • Rates of tobacco use increased between 5 percent and 16 percent.
  • Rates of obesity increased between 4 percent and 9 percent.

In an original investigation, Scientific American took the results of this study one step further. They specifically looked at where in the United States there were the highest increases in stroke among young people. They found that the steepest increases were in the West and Midwest. Additionally, cities saw bigger increases than did rural areas.

Although the South is referred to as the “Stroke Belt,” and the highest absolute number of strokes occur there, the greatest increases in stroke frequency among young people is occurring in the West and Midwest. The number of strokes in the South was already high; thus, the relative increase in stroke frequency isn’t as much as in the West and Midwest, where stroke rates were lower.

Technology could also play a role in the dramatic increase in stroke frequency observed in the West and Midwest. Specifically, in the Northeast, where stroke rates among young people didn’t increase as much, diagnostic imaging like MRI may be more readily available and more strokes may be diagnosed.

With more strokes diagnosed at baseline, there could be a smaller relative increase in stroke frequency. In other words, places like the Northeast wouldn’t have as big of an increase in stroke frequency because the availability of MRI technology means more strokes were diagnosed to begin with.

Use of illicit drugs, such as meth and crack, could play a role in the increase in acute ischemic strokes.

Experts hypothesize that the one reason why strokes are more frequent in urban rather than rural areas is because urban areas are more polluted. Moreover, because many rural hospitals have shuttered in recent years, people living in rural areas could be traveling to urban hospitals for treatment, thus inflating stroke rates of urban areas.

We must keep in mind that all these possible explanations—diagnostic imagery, drugs, pollution, and a paucity of rural health care—are mere conjectures. More research must be done to understand trends in stroke frequency.

Increases in stroke rates among young people complement other increases in cardiovascular risk factors, such as obesity and diabetes.

Obesity

In recent years, the media has reported that there’s been a decline in childhood obesity. This claim, however, is inaccurate. In reality, some research shows that there’s been a decrease in obesity in low-income preschool-aged children or specific geographic areas. This research, however, can’t be extrapolated to the general population. Data from between 2007 and 2010 show that there’s been no decrease in obesity. In fact, there’s been an increase in severe types of obesity in young people.

In a 2014 article published in JAMA Pediatrics, Skinner and Skelton examined serial cross-sections of the U.S. population between 1999 and 2012. These samples included children between 2 and 19 years old.

The researchers found that there may be a stabilization in obesity prevalence. However, there’s been a spike in higher classes of obesity (i.e., BMI of 35 or greater). Of note, more severe forms of obesity are more closely associated with cardiometabolic risk, including stroke.

Type 2 Diabetes

In a 2017 study published in JAMA, Mayer-Davis and co-authors found that the incidence of type 2 diabetes rose between 2002 and 2012. Type 2 diabetes is a cardiovascular risk factor and contributes to stroke.

Using population-based analyses, for kids aged between 10 and 19, they found that there was a 4.8 percent annual increase in the incidence of type 2 diabetes. This increase was particularly pronounced among minority racial and ethnic groups. For instance, among Native American youths, there was an increase from 3.1 percent to 8.9 percent.

Of note, the results of this study concur with findings from previous research done by the same researchers: Between 2001 and 2009, there was also an increase in the prevalence of type 2 diabetes among youth.

Implications

Increased stroke and associated risk factors among young adults is concerning for at least two reasons:

  • Strokes can result in serious disability, and when a young person becomes disabled from a stroke, their ability to make a living is compromised. The emotional and economic impacts not only affect the person with stroke-related disability, but also family members. Strokes can redirect lives for the worse.
  • Although first strokes tend to be milder, a history of stroke in a young person serves as a canary in a coal mine. Future strokes are more serious and debilitating than the first one. Thus, this increase in stroke frequency in young adults could be the initial sign of a much more destructive epidemic that could play out in the next few decades.

Treatment

Identifying a trend in rising stroke and cardiovascular risk factors among young adults is merely a first step. The bigger question is how to treat what can become a serious epidemic.

In a 2015 article in Stroke titled “Obesity Increases Stroke Risk in Young Adults Opportunity for Prevention,” Kernan and Dearborn write the following:

In one camp, are those who see that obesity is associated with increased risk for stroke and say that it as an important target for primary and secondary prevention. In the other, are those who agree that obesity increases stroke but say that it is more effective to treat the consequence of obesity that are responsible for stroke risk (ie, hypertension and dyslipidemia) than obesity itself.

In other words, it’s still unclear whether prevention of stroke should focus on either obesity or conditions that are caused by the obesity, such as high blood pressure and high cholesterol.

The authors argue that if we had better treatment options for obesity, there would be no question that the obesity should be the focus of stroke prevention among young adults. Furthermore, treating hypertension, although a cause in the development of stroke, may leave some other residual factors untreated.

Again, according to the researchers:

[E]ven optimal prescription of risk-reducing therapy (e.g., hypertension therapy) would still leave many young obese patients exposed to untreated risk. This is particularly true because the only practical risk-reducing therapy for mediators of vascular disease in obesity is hypertension therapy. Research has not firmly established that tight control of diabetes mellitus reduces risk for vascular disease; there are no specific therapies recommended for treating the inflammation of obesity, and many young patients are not currently considered candidates for lipid-lowering therapy.

In other words, it’s difficult to treat patients for risk factors for stroke resulting from obesity. Tight control of diabetes has not yet been proven to decrease stroke risk. Moreover, there is no specific way to treat the inflammation that accompanies obesity which predisposes to stroke and heart disease. Finally, many young people wouldn’t qualify for lipid-lowering therapy, such as statins.

A Word From Verywell

Research has pointed to an increase in stroke and related cardiovascular risk factors among young adults. This finding is concerning because it could portent a much larger issue, with a much higher incidence of more serious, acute ischemic stroke in coming years.

Right now, there is no single agreed upon way to prevent stroke, a disease which can be incredibly debilitating and seriously affect individuals and families. The best preventive advice that a young person can follow is to limit risk factors for acute ischemic stroke to begin with. Young people need to avoid becoming obese, avoid smoking, and receive appropriate treatment for hypertension.

Finally, please keep in mind that only a minority of strokes—between 5 and 10 percent—occur in children and young adults. By no means is the number of strokes affecting millennials a majority of strokes. Nevertheless, any case of acute stroke affecting a young person is highly concerning, and increasing trends are a public health priority.

Sources:

George, MG, Tong, X, Bowman, BA. Prevalence of Cardiovascular Risk Factors and Strokes in Younger Adults. JAMA Neurology. 2017;74:695-703.

Kernan, WN, Dearborn, JL. Obesity Increases Stroke Risk in Young Adults Opportunity for Prevention. Stroke. 2015;46:1435-1436.

Maron, DF. More Millennials Are Having Strokes. Scientific American. June 28, 2017. [e-pub]

Mayer-Davis, EJ, et al. Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012. The New England Journal of Medicine. 2017; 376:1419-1429.

Skinner, AC, Skelton, JA. Prevalence and Trends in Obesity and Severe Obesity Among Children in the United States, 1999-2012. JAMA Pediatrics. 2014;168:561-566.

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