The Benefits of Pomegranate Peel Extract

pomegranate peel
Pomegranate peel extract is sourced from the pomegranate fruit.. Verdina Anna/Moment Open/Getty Images

Pomegranate peel extract is a natural substance sold in dietary supplement form. Sourced from the peel of the pomegranate fruit (Punica granatum), it's often touted as a top source of antioxidants (including vitamin C). Use of dietary supplements containing pomegranate peel extract is said to provide a wide range of health benefits, including improvements in heart health.

Research shows that pomegranate peel extract is high in polyphenols (a class of compounds with antioxidant effects).

Pomegranate peel extract has also been found to contain ellagitannins, which are compounds known to reduce inflammation).

Uses for Pomegranate Peel Extract

In alternative medicine, pomegranate peel extract is said to help treat and/or prevent the following health problems:

In addition, pomegranate peel is thought to promote detox, protect against heart disease, fight cancer, shield your skin from sun damage, and offer anti-aging benefits.

Benefits of Pomegranate Peel Extract

A number of studies have shown that compounds in pomegranate peel extract may help fight disease by reducing oxidative stress. However, there's currently a lack of clinical trials testing the health effects of dietary supplements containing pomegranate peel extract.

Still, some preliminary research suggests that pomegranate peel extract holds promise in the treatment of certain health conditions.

Here's a look at several findings from the available research on the potential health benefits of pomegranate peel extract:

1)  High Cholesterol

Several animal-based studies have shown that pomegranate peel extract may help lower cholesterol levels. In a study published in Evidence-Based Complementary and Alternative Medicine in 2014, for instance, tests on rats placed on a high-fat demonstrated that treatment with pomegranate peel extract led to a significant decrease in the animals' total cholesterol.

What's more, pomegranate peel extract appeared to protect the rats from liver damage.

A mouse-based study published in the British Journal of Nutrition in 2013 also found that pomegranate peel extract may help keep cholesterol in check. Another key finding from the study: pomegranate peel extract may help boost health by promoting the growth of probiotic bacteria in the gut.

2)  Diabetes

Pomegranate peel extract may help control diabetes, according to a mouse-based study published in the journal Biofactors in 2007. The study found that polyphenols in pomegranate peel extract may help regulate blood sugar levels, as well as improve insulin levels. 

3)  Cancer

There's some evidence that pomegranate peel extract may have anti-cancer benefits. In a rat-based study published in Asian Pacific Journal of Cancer Prevention, for instance, an experiment on rats showed that pomegranate peel extract may inhibit the development of colon cancer.

Furthermore, a preliminary study published in the Journal of Medicinal Food in 2011 shows that pomegranate peel extract may help combat breast cancer.

In their research on human breast cancer cells, the study's authors observed that pomegranate peel extract may help thwart the growth and spread of breast cancer partly by inducing apoptosis (a type of programmed cell death essential for stopping the proliferation of cancer cells).


Due to the lack of clinical trial testing the effects of dietary supplements containing pomegranate peel extract, little is known about the safety of long-term or regular use of such supplements. If you're considering the use of dietary supplements containing pomegranate peel extract, consult your physician prior to starting your supplement regimen.

You can learn more about how to use dietary supplements safely here.

Where to Find It

Dietary supplements containing pomegranate peel extract are sold in many stores specializing in natural products, including natural-foods stores. You can also purchase pomegranate peel extract online.

Using Pomegranate Peel Extract for Health

Due to the limited research, it's too soon to recommend pomegranate peel extract as a treatment for any condition. It's also important to note that self-treating a condition and avoiding or delaying standard care may have serious consequences. If you're considering using it, make sure to consult your physician first.


Dikmen M1, Ozturk N, Ozturk Y. "The antioxidant potency of Punica granatum L. Fruit peel reduces cell proliferation and induces apoptosis on breast cancer." J Med Food. 2011 Dec;14(12):1638-46.

Ismail T1, Sestili P, Akhtar S. "Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects." J Ethnopharmacol. 2012 Sep 28;143(2):397-405.

Kumar AK1, K V. "Protective Effect of Punica granatum Peel and Vitis vinifera Seeds on DEN-Induced Oxidative Stress and Hepatocellular Damage in Rats." Appl Biochem Biotechnol. 2014 Oct 11.

Kumar D1, Singh S, Singh AK, Rizvi SI. "Pomegranate (Punica granatum) peel extract provides protection against mercuric chloride-induced oxidative stress in Wistar strain rats." Pharm Biol. 2013 Apr;51(4):441-6.

Neyrinck AM1, Van Hée VF, Bindels LB, De Backer F, Cani PD, Delzenne NM. "Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota." Br J Nutr. 2013 Mar 14;109(5):802-9.

Parmar HS1, Kar A. "Antidiabetic potential of Citrus sinensis and Punica granatum peel extracts in alloxan treated male mice." Biofactors. 2007;31(1):17-24.

Sadeghipour A1, Eidi M2, Ilchizadeh Kavgani A3, Ghahramani R4, Shahabzadeh S3, Anissian A5. "Lipid Lowering Effect of Punica granatum L. Peel in High Lipid Diet Fed Male Rats." Evid Based Complement Alternat Med. 2014;2014:432650.

Singh RP1, Chidambara Murthy KN, Jayaprakasha GK. "Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models." J Agric Food Chem. 2002 Jan 2;50(1):81-6.

Waly MI1, Ali A, Guizani N, Al-Rawahi AS, Farooq SA, Rahman MS. "Pomegranate (Punica granatum) peel extract efficacy as a dietary antioxidant against azoxymethane-induced colon cancer in rat." Asian Pac J Cancer Prev. 2012;13(8):4051-5.

Disclaimer: The information contained on this site is intended for educational purposes only and is not a substitute for advice, diagnosis or treatment by a licensed physician. It is not meant to cover all possible precautions, drug interactions, circumstances or adverse effects. You should seek prompt medical care for any health issues and consult your doctor before using alternative medicine or making a change to your regimen.

Continue Reading