What Is the Hormone Theory of Aging?

The Endocrine System and Aging

Close up of mid adult woman and her grandmother holding hands
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Could your hormones be aging you? There are many theories behind why we age, and one is the hormone theory of aging. Experts who back this idea believe hormones, which control the function of organs, could be behind aging — and maybe even the fountain of youth. Learn more about how hormones might be the culprit behind the aging process.

Hormone Theory of Aging

The hormone, or endocrine theory, of aging asserts that the most important factors in aging are the changes brought about in the body by the endocrine system.

The complex endocrine system of our body controls the hormones that regulate many body processes. As we age, these systems become less efficient, leading to changes in our bodies, such as menopause. The hormone theory of aging states that these changes eventually cause the effects of aging.

Do Hormones Cause Aging?

There is some evidence to support the hormone theory of aging. In one study, researchers removed the pituitary gland of mice, which controls much of the endocrine system. The researchers then substituted the absence of the pituitary gland with supplementation of all of the hormones identified in mice. It turns out that those without a pituitary gland lived longer than a control group of normal mice who did have a gland. This led researchers to conclude that the pituitary gland must also excrete another, unknown, a hormone that negatively impacts aging.

Hormones for Anti-Aging

The concept that hormones might cause aging has also led some to believe that they could be an anti-aging elixir.

Growth hormone, which is produced in the pituitary gland, helps maintain tissues and organs throughout life. It's also responsible for childhood growth. Synthetic human growth hormone (HGH) has been developed as a potential fountain of youth, with proponents hoping it can stave off the decline in tissue growth from aging.

While some adults have growth hormone deficiencies and require supplementation, this is rare. Research is indecisive on any other potential benefits. In addition, the use of HGH has many potential side effects, especially in older adults, including swelling of the arms and legs, joint and muscle pain, carpal tunnel syndrome and enlargement of breast tissue in men.

The Takeaway

Hormonal changes are an important part of aging. Whether they control the pace at which aging happens or are a consequence of other changes in the body is unknown. It is unlikely that hormone substitution in humans will increase lifespan and can even be dangerous. Some anti-aging doctors will prescribe HGH, but research does not support its use for anti-aging.

You might be surprised to learn that there are tons of other theories of aging. Want to know more? Check out these resources to read up on some of the other theories of aging:

Most Popular Anti-Aging Hormones

Programmed Theories of Aging

Rate of Living Theory of Aging

Telomere Shortening - The Secret to Aging?

The Basics of the Immunological Theory of Aging

The Genetic Theory of Aging

Theories and Effects of Aging

The Wear and Tear Theory of Aging

What Is the Somatic Mutation Theory of Aging?

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