Tirosint - Hypoallergenic Liquid Gelcap Levothyroxine Thyroid Drug

tirosint, levothyroxine

Tirosint is a brand name levothyroxine hormone replacement drug. Here are some common questions and answers, as well as further information about Tirosint.   

What Sort of Medication Is Tirosint?

Tirosint is a brand name for levothyroxine sodium (like Synthroid, Levoxyl, and Unithroid.) Levothyroxine sodium is a thyroid hormone replacement drug used to treat hypothyroidism.

How Is Tirosint Different From Other Brand Names of Levothyroxine?

The levothyroxine in Tirosint is in a liquid form, inside a soft gelatin capsule.

It is the first and only liquid levothyroxine in a capsule. Other brand name levothyroxine drugs are in tablet form. 

Tirosint comes with each capsule in a blister pack -- not loose in a bottle -- and the blister pack is marked to help prevent patients from missing doses.

Tirosint capsules are hypoallergenic and contain no dyes, gluten, alcohol, lactose, or sugar.Tirosint is specifically designed for patients with allergies to fillers and dyes found in levothyroxine tablets, and for those patients with celiac disease, Crohn's disease, irritable bowel syndrome, or digestive or absorption problems that make traditional tablets less effective for them.

What Dosages Are Available?

Tirosint is available in 13 mcg, 25 mcg, 50 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg, 137 mcg, and 150 mcg dosage sizes.

Is there anyone who can't take Tirosint?

Parents who administer levothyroxine to infants and children often crush or dissolve the tablets.

Unlike levothyroxine sodium tablets, however, Tirosint capsules cannot be cut or crushed.

This means they are not suitable for infants, and children or any other thyroid patients who are unable to swallow whole capsules.

Who Makes Tirosint?

Tirosint is marketed and distributed by Akrimax Pharmaceuticals and manufactured by IBSA Institut Biochimique, a privately-owned, global pharmaceutical company headquartered in Lugano, Switzerland.

The U.S. contact location for Akrimax is 11 Commerce Drive, 1st Floor, Suite #100, Cranford, NJ 07016.

Their website is www.akrimax.com. Their main contact number is (908) 282-7234.

Where Can Doctors Get More Information About Tirosint?

The product information page for Healthcare professionals is online, and the contact number at Akrimax for more information on Tirosint is 908-372-0506.

Akrimax Patient Assistance Program

The Akrimax Patient Assistance Program is available to patients who meet specific income requirements, and those who are eligible can receive Tirosint for free for up to one year, with monthly Tirosint shipments by mail to eligible patients. Patients can re-enroll in the program after one year of participation. For more information (including eligibility requirements), patients can call 855-856-6915.

Akrimax Direct Program

The Akrimax Direct program offers patients the option for direct mail ordering of prescription Tirosint.

The pharmacy handling the program -- Linden Care -- will determine whether your insurance copay or the cash price is the lowest cost option. This includes the value of the Tirosint coupon currently available for Tirosint at the Tirosint website. Please note that they are not honoring any other coupons.

You can receive your medication by standard USPS delivery for free -- it usually takes five days -- or by Federal Express overnight or second-day delivery at additional cost.

You can enroll by phone by calling 877-954-6336. 

After you and your doctor complete the form, sign it, and fax it, along with a copy of your prescription, to 1-516-308-4339 or email the form and scanned prescription to glennb@lindencare.com.

If you already have a prescription, you can get it transferred to the Akrimax Direct Program by calling Linden Care at 877-954-6336. You will need to have the pharmacy name, location, phone number, prescribing physician and prescription number, and Linden Care will handle the transfer for you.


Most thyroid patients are aware that drinking coffee with -- or a few minutes after -- taking regular levothyroxine prevents proper absorption of the medication. (See Coffee and Thyroid Medication.)

But research presented at the American Thyroid Association meeting in 2011 reported that thyroid patients who drank coffee around the time they took Tirosint did not experience impaired absorption.

The Tirosint softgel capsule appears to be "coffee-resistant" and according to the researchers, can be used to achieve a target TSH level -- and proper medication absorption -- in patients who are unwilling or unable to change the way they take their levothyroxine.

Interestingly, even in patients who do not drink coffee within an hour of taking their medication,  TSH testing suggested that patients were achieving better absorption using the Tirosint, as compared to levothyroxine in tablet form.


S. Benvenga, et. al. "A Novel Formulation of L-Thyroxine (L-T4) Solves Problems of L-T4 Malabsorption Caused by Coffee in Patients Under Replacement or TSH Suppressive L-T4 Therapy with Conventional Tablets," Abstracts of the American Thyroid Association Annual Meeting, 2011