Top 5 Deadliest Cancers

The Biggest-Killing Cancers out There


Cancer cells divide, grow and spread throughout the body.  If physicians are unable control the spread or metastases of cancer cells, death results. 

Various factors, both internal and external, cause cancer.  Internal factors include genetic mutations, hormones and immune conditions.  External factors include smoking, unhealthy diet and infectious disease.  Often, it takes several years before such risk factors cause cancer.

According to the American Cancer Society, in 2015, an estimated 1,658,370 million new cases of cancer are expected among Americans, and 589,430 people will die of the disease.

Here are the 5 deadliest cancers.

Deadliest Cancer #1: Lung Cancer


Projected cases of lung and bronchus cancer in 2015: 221,200

Projected deaths caused by lung and bronchus cancer in 2015: 158,040

Unfortunately, most people with lung cancer initially present with advanced disease and will eventually die of the disease.  Smoking--a modifiable risk factor--is far and away the most common cause of lung cancer.  Based on microscopic examination, lung cancer is divided into 2 types: small-cell lung cancer and non-small cell lung cancer.  Depending on the type and stage of the lung cancer, treatment can include surgery, chemotherapy and radiotherapy.

Deadliest Cancer #2: Colorectal Cancer


Projected cases of colorectal cancer in 2015: 132,700

Projected deaths caused by colon cancer in 2015: 49,700

Initially, colorectal cancer presents with few or no symptoms.  If caught early, colorectal cancer is treatable with encouraging 5-year survival rates.  For example, survival rates for some people with early-stage colorectal cancer are around 90 percent.  However, in order to survive colorectal cancer, screening like colonoscopy is imperative.  Unfortunately, five-year survival rates for advanced colorectal cancer are much lower.  Depending on the stage and spread of colorectal cancer, treatment can include surgery, radiotherapy, chemotherapy or embolization

Deadliest Cancer #3: Breast Cancer


Projected cases of breast cancer in 2015: 234,190

Projected deaths caused by breast cancer in 2015: 40,730

Breast cancer is caused by the malignant growth of cells lining the lobules or ducts of the breast.  About one percent of all breast cancers affect men.  Breast cancer arises from a clone or single transformed cell.  Typically, it takes time for such clonal cells to become fully malignant and invade and metastasize.

The treatment of breast cancer can get quite complicated and is based on numerous variables.  Broadly, breast cancer treatment can be characterized as extensive (mastecotmy) or breast-conserving (lumpectomy).  In addition to local surgical therapy, adjuvant or systemic therapy is also given to treat people with breast cancer.  Such adjuvant therapy can include chemotherapy or hormone therapy.  Fortunately, with improvements in diagnostic and treatment capabilities, more people are surviving breast cancer.

Deadliest Cancer #4: Pancreatic Cancer


Projected cases of pancreatic cancer in 2015: 48,960

Projected deaths caused by pancreatic cancer in 2015: 40,560

Pancreatic cancer is one of the worst cancers out there.  It kills quickly and besets the patient with multiple painful and dangerous symptoms including stomach pain, biliary obstruction, bleeding, ascites and more.  Despite research into the subject, there are no good screening options or treatments for people pancreatic cancer.

Deadliest Cancer #5: Prostate Cancer


Projected cases of prostate cancer in 2015: 220,800

Projected deaths caused by prostate cancer in 2015: 27,540

The prostate is a gland found in men only.  It sits in the middle of the lower pelvis nestled among the rectum and bladder.  The prostate makes seminal fluid which nourishes sperm.

Prostate cancer arises from glandular cells and is thus an adenocarcinoma.  This disease usually affects older men and is most common among African Americans and those with a family history of the disease.  Most prostate cancers are slow growing, and people with asymptomatic prostate cancer are usually observed with no further treatment.  In fact, many people with prostate cancer die of unrelated causes like heart attack or stroke.

Treatment of prostate cancer includes surgical removal (prostatectomy), external beam radiation therapy (radiotherapy) and brachytherapy.  Brachytherapy is a procedure where radioactive iodine is implanted into the prostate.

Although asymptomatic older men were once routinely screened for prostate cancer by both digital rectal exam and prostate-specific antigen (PSA) test, in recent years, such routine screening has fallen out of favor among many medical experts.  Although Medicare still covers such screening, many experts believe that benefits from such screening are negligible.

Top 5 Deadliest Cancers: Conclusion


It's dismaying how many people suffer from and die of cancer each year.  The good news is that if caught early--before spread or metastases--some forms of cancer are preventable and treatable.  If you or a loved one suspects cancer, it's imperative that you immediately make an appointment with a primary care physician or specialist who can help.  Please remember that with cancer, time is of the essence.  Simply ignoring symptoms can be deadly, and gives the cancer time to spread throughout your body. 

Selected Sources

"Cancer Facts & Figures 2015" published by the American Cancer Society

Lippman ME. Chapter 90. Breast Cancer. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds. Harrison's Principles of Internal Medicine, 18e. New York, NY: McGraw-Hill; 2012. Accessed April 12, 2015.

Morgensztern D, Govindan R, Perry MC. Chapter 97. Lung Cancer. In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S. eds. Hazzard's Geriatric Medicine and Gerontology, 6e. New York, NY: McGraw-Hill; 2009. Accessed April 12, 2015.

Pienta KJ. Chapter 96. Prostate Cancer. In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S. eds. Hazzard's Geriatric Medicine and Gerontology, 6e. New York, NY: McGraw-Hill; 2009. Accessed April 12, 2015.


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