Ultram for Fibromyalgia

Most Recommended Opiate for Fibromyalgia Pain

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What Ultram Is

Ultram (tramadol) is an analgesic (pain killer) prescribed for moderate to severe pain. It's an opiate (narcotic) and also a monoamine uptake inhibitor, which means that it makes more of certain neurotransmitters available to your brain.

Ultram is also used to treat most types of neuralgia (nerve pain.) It's sometimes used off-label for fibromyalgia, restless legs syndrome, migraines, and obsessive-compulsive disorder.

Ultram ER (extended release) is available for controlling severe chronic pain 24 hours a day.

How Ultram Works

Ultram appears to work in a couple of ways:

  • Impacting certain opioid receptors in the brain;
  • Increasing available amounts of the neurotransmitters serotonin and norepinephrine.

Those chemicals can be low in people with fibromyalgia. Serotonin is involved with pain processing and the sleep cycle. Norepinephrine helps your body deal with stress. Both may play some role in many symptoms of this condition.

Ultram for Fibromyalgia

Ultram is not FDA approved for treating fibromyalgia pain, but it is sometimes prescribed off-label for the condition.

We have a few studies demonstrating that it may be effective, including at least one that suggests it's the only narcotic pain killer demonstrated to help with the unique pain types of fibromyalgia.

An animal study published in June 2009 (Kim) shows that it may be especially effective against the hyperalgesia of fibromyalgia when combined with Savella (milnacipran), but these results have not yet been replicated in humans.

A 2015 study (Peng) suggested that people with fibromyalgia taking tramadol had fewer doctor's visits.

A review of literature on the drug (MacLean) concluded that there was fair evidence supporting its use as a second-line treatment for people who needed more pain relief than FDA-approved drugs provide.

Ultram Dosage

To lessen the risk of side effects, Ultram is generally started at a dose of 25 mg a day and increased gradually to 100-200 mg a day.

Be sure to follow your doctor and pharmacist's instructions on increasing your dosage. More than 400 mg per day is considered dangerous for most adults. The safety cut-off for those older than 75 is 300 mg per day.

Ultram Side Effects & Warnings

Like all medications, Ultram does carry a risk of unpleasant side effects. Side effects that you should report to your doctor right away include:

  • Breathing difficulties or wheezing,
  • Confusion,
  • Itching,
  • Light headedness or fainting,
  • Red, blistering, peeling or loosening skin,
  • Seizures.

Side effects that usually don't require immediate medical attention include:

  • Constipation,
  • Dizziness,
  • Drowsiness,
  • Headache,
  • Nausea or vomiting.

If these side effects continue or are a problem for you, talk to your doctor about them.

If you have a history of drug or alcohol addiction, you shouldn't take Ultram. This drug has caused seizures in some people, and can make it more likely that you'll have a seizure if you have a history of seizures, head injury, a metabolic disorder, or you're taking certain medications (antidepressants, muscle relaxers, drugs for nausea and vomiting.)

You may need a special dosage or tests to safely take Ultram if you have:

  • Kidney disease,
  • Liver disease,
  • A stomach disorder,
  • History of depression, mental illness, or suicide attempts.

Also note: When planning to stop taking Ultram, you will need to discontinue dosages slowly to avoid withdrawal symptoms. Talk to your doctor or pharmacist about how to safely wean off of it.

Is Ultram Right for You?

If you'd like to try Ultram, talk to your doctor. You should weight the possible pros and cons carefully before making a decision. If you start taking Ultram, be sure to watch for side effects.


Goldenberg DL. Best Practice & Research. Clinical Rheumatology. 2007 Jun;(3):499-511. Pharmacological treatment of fibromyalgia and other chronic musculoskeletal pain.

Huynh CN, Yanni LM, Morgan LA. Journal of Women's Health. 2008 Oct;17(8):1379-87. Fibromyalgia: diagnosis and management for the primary healthcare provider.

Kaneko K, et al. Neuroscience letters. 2014 Mar 6;562:28-33. The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgia.

Kim SH, et al. Korean Journal of Internal Medicine. 2009 Jun;24(2):139-42. Effect of the combined use of tramadol and milnacipran on pain theshold in an animal model of fibromyalgia.

MacLean AJ, Schwartz TL. Expert review of neurotherapeutics. 2015 May;15(5):469-75. Tramadol for the treatment of fibromyalgia.

Peng X, et al. Clinical journal of pain. 2015 Jan;31(1):7-13. Long-term evaluation of opioid treatment in fibromyalgia.

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