Placebo and Alternative Medicine

placebo pills
A placebo resembles an active treatment. WLADIMIR BULGAR/Science Photo LIbrary/Getty Images

A placebo is an inactive, look-alike, or fake treatment that does not contain an active substance meant to affect health, but when administered to a person under the pretext of being a treatment, may improve a person's condition simply because he or she expects that it will help.

Usually resembling a regular treatment or medicine, placebos could be pills, tablets, or capsules that look like a medication but are composed of sugar, starch, saline or other inactive substances, or it could be a shot, a liquid, a procedure, or even a visit to the doctor.

Any change in symptoms that is measured, observed, or felt after the placebo is given is called the placebo effect or the placebo response. Symptoms may improve, or a person may experience what appears to be side effects. A placebo can produce physiological effects such as changes in blood pressure, heart rate, and brain activity.

The placebo effect is thought to occur more strongly in certain health conditions such as pain, depression, anxiety, osteoarthritis, Parkinson's disease, headache, hot flashes, cold symptoms such as cough, and skin itchiness.

How Are Placebos Used in Research?

In clinical trials, a placebo may be compared to a new treatment to see if any effects that happen with the new treatment are actually caused by the treatment and not something else (such as expectations about the treatment).

In a double-blind placebo-controlled study, the placebo must be convincing enough that the patient and the person administering the treatment do not know who is receiving the treatment and who is getting the placebo, so that their expectations don't influence the outcomes.

Participants in a clinical trial using a placebo must always be informed about the possibility that they could be receiving a placebo.

Placebos in Complementary and Alternative Medicine

The placebo effect is often used when discussing why people report improvements with complementary and alternative medicine (CAM).

Critics often point to the lack of scientific evidence (specifically randomized controlled trials) demonstrating that CAM therapies, such as acupuncture, are more effective than a placebo. The growing field of CAM research should include randomized controlled trials to help distinguish between a therapeutic effect and a placebo effect.

Pronunciation:

Pluh-SEE-bo

Example:

"Although there have been preliminary studies on the effectiveness of reiki for various health conditions, there is a lack of well-designed, reproducible studies showing that reiki is more effective than a placebo."

Related: 6 Herbs for Pain Relief and 15 Remedies for Back Ache Relief

Sources:

Darragh M, Vanderboor T, Booth RJ, Sollers JJ 3rd, Consedine NS. Placebo 'serotonin' increases heart rate variability in recovery from psychosocial stress. Physiol Behav. 2015 Jun 1;145:45-9. doi: 10.1016/j.physbeh.2015.03.043. Epub 2015 Mar 31.

Relton C.& Implications of the 'placebo effect' for CAM research. Complement Ther Med. 2013 Apr;21(2):121-4. doi: 10.1016/j.ctim.2012.12.011. Epub 2013 Jan 18.

Segar J. Complementary and alternative medicine: exploring the gap between evidence and usage. Health (London). 2012 Jul;16(4):366-81. doi: 10.1177/1363459311425516. Epub 2011 Oct 21.

van Laarhoven AI1, van der Sman-Mauriks IM2, Donders AR3, Pronk MC2, van de Kerkhof PC4, Evers AW1. Placebo effects on itch: a meta-analysis of clinical trials of patients with dermatological conditions. Invest Dermatol. 2015 May;135(5):1234-43. doi: 10.1038/jid.2014.522. Epub 2014 Dec 1.

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