What is Anti Mullerian Hormone or AMH?

what is AMH?
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Question: What is Anti Mullerian Hormone or AMH?

 

Answer:

What is AMH?

Anti Mullerian Hormone (AMH) also called Mullerian Inhibiting Substance, is a special protein released by cells that are involved with the growth of an egg follicle each month. AMH levels correlate with the number of antral follicles found on the ovary each month; the higher the antral follicle count, the higher the AMH levels. Because women with PCOS typically have high numbers of antral follicles, high AMH levels are often seen as well.

Besides being used as a potential diagnostic marker for PCOS, AMH is now sometimes used as an indicator of ovarian reserve in older women.

How is AMH Tested?

AMH can be tested through a regular blood test. Not every physician may offer this test, so check with the office beforehand. It can be drawn during any day of the menstrual cycle and is sent to a special lab for analysis. You may want to check with your insurance provider first about the cost of getting your AMH tested. Not all insurance providers cover the cost of AMH testing.

What are Normal AMH Levels?

Normal AMH levels range between 0.7ng/ml to 3.5ng/ml. Levels below 0.3ng/ml are considered low, and indicate that lower numbers of eggs are within the ovary and decreased fertility. Between 0.3ng/ml to 0.7ng/ml are borderline low. Levels between 3.5ng/ml to 5.0ng/ml are borderline high, while anything above 5.0sng/ml is a high value and can indicate PCOS.

How AMH Is An Important Feature of PCOS

New research is starting to show that AMH levels go beyond checking ovarian reserve in women with PCOS, and could even be used as a diagnostic criteria in women. A review published in the Journal of Rerproductive Biology and Endocrinology, suggested serum AMH could be considered the “Gold Standard” in the diagnosis of PCOS.

 AMH level is correlated to the severity of PCOS symptoms and is higher in women with high androgens and irregular menstrual cycles. Early diagnosis and treatment are important for women with PCOS. Checking AMH levels could be particlarly helpful for diagnosing young women with PCOS. 

Updated by About.com PCOS Expert Angela Grassi, MS, RDN, LDN

Sources:

Dumont A1, Robin G2, Catteau-Jonard S3, Dewailly D4.Role of Anti-Müllerian Hormone in pathophysiology, diagnosis and treatment of Polycystic Ovary Syndrome: a review.Reprod Biol Endocrinol. 2015 Dec 21;13(1):137.

Pellatt L, Rice S, Mason HD. Anti-Mullerian hormone and polycystic ovary syndrome: a mountain too high? Reproduction (Cambridge, England) 2010;139(5):825–33

Anti Mullerian Hormone and Mullerian Inhibiting Substance. Repromedix. Updated February 2007. Accessed 20 August 2008 from http://www.repromedix.com/pdf/AMHbL17CF181.pdf.

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