What Is Arthri-D for Arthritis?

Infomercial Touts the Effectiveness of Arthri-D for Arthritis

Man reading label on Arthri-D.
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Arthri-D is a dietary supplement that combines glucosamine with specific plant extracts. If you watch television late at night, you may have seen the infomercial for Arthri-D. Infomercials are immediate turn-offs for some people, but others pay close attention to anything that claims to relieve arthritis pain.

The infomercial and website for Arthri-D states that it is a "revolutionary formula that combines one of the highest grades of glucosamine with key plant extracts." People with arthritis have been taught to be wary of remedies that are marketed using words like "revolutionary" and "promise", or phrases like "changed my life".

We are repeatedly warned to steer clear of hype.

That said, let's keep an open mind just long enough to determine how Arthri-D claims to be different from other dietary supplements. Arthri-D is an all-natural dietary supplement that is fortified with:

  • 2000 IU of vitamin D3
  • N-acetyl-glucosamine (which they market as being better than cheaper forms of glucosamine)
  • Turmeric
  • Boswellia
  • Ashwagandha (an antioxidant thought to promote energy, as well as help the body utilize other herbs)
  • Yucca (sold in supplements across North America for more than 50 years)

Indications for Arthri-D

Arthri-D is said to help arthritis, including rheumatoid arthritis, osteoarthritis, fibromyalgia and even gout.

How Is Arthri-D Taken?

Each bottle of Arthri-D contains 120 capsules (a one-month supply). Directions say that you should take two capsules in the morning and two in the afternoon or evening. You may take with or without food, but the manufacturer's website states that many experts suggest taking with a meal, which supposedly helps Arthri-D work more effectively.

The manufacturer's research experts recommend trying it for three months before concluding it doesn't work for you.

Availability of Arthri-D

The regular retail price of one bottle of Arthri-D is $109.99 plus $9.99 shipping and handling. There are cost-saving programs—discounts offered by the manufacturer, if you purchase multiple bottles of Arthri-D.

Also, there is a Monthly Replenishment Auto-Shipment Program where, after 90 days, you receive one bottle monthly for $99.99 retail customer / $74.99 Ambassador customer plus $9.99 shipping and handling.

Precautions and Warnings for Arthri-D

Because Arthri-D contains N-acetyl-glucosamine, an all-natural derivative of shellfish, anyone with an allergy to shellfish should avoid Arthri-D. Also, if you are pregnant or nursing, do not use Arthri-D without consulting a physician.

A Word From Verywell

It is important to look beyond the marketing hype and keep your expectations real for Arthri-D. There is a disclaimer on the Arthri-D website which states "Individual results may vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease." The portion of the statement regarding "not intended to diagnose, treat, cure or prevent any disease" actually pertains to all dietary supplements.

Have you wondered why Arthri-D claims to use a superior grade of glucosamine and what difference that may make? They explain it this way: For the body to use glucosamine, structurally it must be converted into N-acetyl-glucosamine first.

Many people make the conversion easily, but not everyone. According to Arthri-D, by taking N-acetyl-glucosamine supplements, you can skip the conversion reaction and get the same benefits as someone who can effortlessly convert the regular forms of glucosamine (e.g., glucosamine hydrochloride and glucosamine sulfate). But, Arthri-D doesn't back up such claims with scientific evidence. I, however, did find a study published in Osteoarthritis and Cartilage (2009) which concludes glucosamine and N-acetyl-glucosamine do have distinct molecular mechanisms mediating their differential biological activities in chondrocytes.

But, wouldn't you try cheaper forms first, to see if you are among the easy converters? Just a thought. Talk to your doctor about it.



Shikhman, Alexander R. Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes. Osteoarthritis and Cartilage. 2009 Aug; 17(8): 1022–1028.