What Is Instaflex?

Instaflex Is #1 Selling Joint Supplement at GNC

Instaflex is used to treat joint pain.
Instaflex is used to treat joint pain. BSIP/UIG/Getty Images

One dietary supplement for better joint health that has caught my eye in magazine ads and on television commercials is Instaflex. The name makes it sound as though it can provide instant pain relief and better flexibility. Two well-known athletes gave testimonials for Instaflex -- college and professional football quarterback Doug Flutie and U.S. women's soccer player Carla Overbeck.

However, Instaflex is quite expensive, and you will want to research it to determine if you still think it is worth the price.

How Quickly Does Instaflex Work?

According to the Instaflex website, "Instaflex begins working from your very first dose, most notice a substantial difference after seven days. We recommend, however, that users take Instaflex for a minimum of three months to observe full effects."

Warnings for Use of Instaflex

Instaflex Joint Support contains crustacean shellfish (shrimp, crab). People with allergies to shellfish should not take Instaflex Joint Support. Also, according to their website, "if you are pregnant, nursing, taking medication, or have a history of heart conditions, we suggest consulting with a physician before using Instaflex." (Note: Instaflex contains no gluten).

Instaflex has introduced a Vegetarian Joint Support formulation that eliminates the use of shellfish.

Instaflex Formulations

There are several formulations of Instaflex, with different ingredients that are popular with joint and muscle supplements.

More varieties are likely to be developed over time, and the ingredients and names of the original formulations may change. Be sure to read the label on the product that you are buying to see what the current formulation contains.

Instaflex Advanced

This formulation needs only to be taken as a single capsule per day, and it is aimed at providing relief in seven days.

It contains turmeric extract, resveratrol, Boswellia serrata extract, UC-II undenatured collagen, hyaluronic acid, and black pepper extract standardized to 95% piperine.

Instaflex Joint Support

Instaflex Joint Support contains eight active ingredients. The daily dosage is three capsules taken together in the morning or evening. It contains these eight supplements: Glucosamine Sulfate, Methylsulfonylmethane (MSM), White Willow Bark Extract, Ginger Root Concentrate, Boswellia Serrata Extract, Turmeric Root Extract, Cayenne, Hyaluronic Acid.

Instaflex Bone Support

Instaflex Bone Support also has a recommended daily dosage of three capsules a day, which contain six active ingredients: Calcium Carbonate, Vitamin D3, Ipriflavone, Horsetail Herb, Glucosamine Sulfate, Silica.

Instaflex Multivitamin

Instaflex Multivitamin, with a recommended dosage of one per day, contains an array of vitamins, including 3,500 IU of Vitamin A, 90 mg of Vitamin C, 500 IU of Vitamin D, 50 IU of Vitamin E, 30 mcg of Vitamin K, 1.5 mg of Thiamine (vitamin B-1), and several more.

Instaflex Muscle Support

Instaflex Muscle Support is formulated to reduce muscle cramps, decrease soreness, and hasten muscle healing. The daily recommended dose is three capsules per day.

The six active ingredients are: Vitamin D3, Vitamin E, Calcium, Magnesium, Potassium, L-Glutamine Monohydrate.

A Closer Look at What's in Instaflex Joint Support

Glucosamine Sulfate - Glucosamine sulfate is a normal component of glycosaminoglycans in the matrix of cartilage and synovial fluid. The supplement is derived from shellfish. The effectiveness of glucosamine for building cartilage and improving the health of joints has been debated for years, and its use is not recommended by the American Academy of Osteopathic Surgeons for knee osteoarthritis. But its popularity has survived the debate.

MSM - Methylsulfonylmethane is normally found in the human diet -- in plants, fruits, vegetables, meats, and dairy. MSM is also found in the human adrenal gland. MSM is thought to have anti-inflammatory properties. Studies have revealed that MSM modestly reduced pain and swelling, but did not relieve joint stiffness.

Willow Bark - The use of willow bark dates back to Hippocrates (400 BC) when patients were advised to chew on it to decrease inflammation and fever. Willow bark is still used today to relieve pain related to low back pain, osteoarthritis, headache, and inflammatory conditions. The bark of white willow contains salicin, a chemical similar to aspirin. Salicin was used to develop aspirin in the 1800s.

Ginger Root - Ginger may have anti-inflammatory effects due to inhibition of COX and lipoxygenase. It may also affect tumor necrosis factor, as well as the synthesis of inflammatory prostaglandins. The aforementioned are enzymes or cytokines involved in the inflammation response. There is no evidence to support recommending ginger for osteoarthritis, according to reports.

Boswellia Serrata - Boswellia serrata has been used in Ayurveda for thousands of years. An enriched extract of the plant can be used as a successful treatment for osteoarthritis. There were no major adverse effects in the osteoarthritis patients involved in studies for Boswellia.

Cayenne - Cayenne is a spice derived mainly from two cultivated species of the Capsicum genus, Capsicum annuum L. and Capsicum frutescens L. The level of pungency or heat of the Capsicum species depends primarily on capsaicin, the active ingredient in cayenne. Studies involving cayenne or capsaicin primarily involved the ingredient in topical form.

Hyaluronic Acid - Hyaluronic acid may have a protective effect on cartilage, and may reduce the production and activity of chemicals involved in inflammation.

The Bottom Line on Instaflex

The maker of Instaflex Joint Support designed its product to be an all-encompassing joint solution, bringing the most effective supplements together in one product. The product launched in the summer of 2010 in the U.S. in GNC stores.

The product is marketed as a high-quality solution that contains "proven ingredients." As with all supplements, keep your expectations realistic. Learn about the ingredients. Talk to your doctor to see if he feels Instaflex is worth a try. It should be noted that according to a marketing representative from Instaflex, "We do not have full product studies, only ingredients. We are working on getting these studies."


Dietary Supplements for Osteoarthritis. P. Gregory, M. Sperry, A. Wilson. American Family Physician. January 15, 2008.

Instaflex. Instaflex.com. Accessed 1/11/2016.

Willow Bark. University of Maryland Medical Center. 12/11/2010.

Cayenne. Complementary Medicine. University of Maryland Medical Center. 12/12/2010.

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