What You Need To Know About Methotrexate (Rheumatrex)

Usage, Side Effects, Dosage, and Use Of Methotrexate In Pregnancy

Methotrexate 15 mg
Methotrexate is used to treat several different forms of cancer, inflammatory arthritis, and Crohn's disease. Image © Pillbox, National Library of Medicine

What Is Methotrexate?

Methotrexate belongs to the class of drugs known as antineoplastics. Antineoplastics impede the body’s natural chemical processes, such as DNA production and cell division. They are helpful in cancer treatments, because they will prevent cancer cells from thriving. Methotrexate may also be given to treat akylosing spondylitis, rheumatoid arthritis, psoriasis, and Crohn’s disease

How Is Methotrexate Taken?

Methotrexate should be taken exactly as prescribed by the doctor. A physical will tailor the dosage to the needs of each individual patient. Methotrexate may be given as a tablet, infusion or injection. If it is taken once a week, it's best to take it on the same day every week.

Why Is Methotrexate Prescribed?

Because methotrexate blocks cell metabolism, it is prescribed for conditions where abnormal cell growth is a problem, such as psoriasis or cancer. Methotrexate has also been found useful for treating some cases of Crohn’s disease and rheumatoid arthritis. Methotrexate has also been used to induce miscarriage in ectopic pregnancies.

Who Should Not Take Methotrexate?

Tell your doctor if you have ever had any of the following conditions:

  • Currently pregnant
  • Kidney disease
  • Liver disease or cirrhosis
  • Lung disease or fibrosis
  • Neurologic disease
  • Recurrent infections

What Are The Side Effects?

Bothersome side effects of methotrexate include headache, drowsiness, itching, skin rash, dizziness, and hair loss.

Serious side effects include toxicity of the liver, bone marrow or, rarely, lungs. See the methotrexate side effects page for a complete list.

Are There Any Food Interactions?

Alcoholic beverages should not be consumed while taking methotrexate, as it could cause damage to the liver, leading to cirrhosis.

What Medications Can Methotrexate Interact With?

People taking methotrexate should avoid vaccinations with a live virus. Methotrexate causes the body’s immune system to be suppressed, so the live virus vaccine may actually cause illness instead of an immune response.

The FDA recommends caution in taking methotrexate along with a proton pump inhibitor (PPI), which are drugs that help reduce the amount of acid in the stomach. Some common PPIs include Prilosec (omeprazole), Nexium (esomeprazole), and Protonix (pantoprazole). The concern is largely indicated in those who are taking higher doses of methotrexate. The problem is that PPIs may increase serum levels (the amount found in the blood) of methotrexate. High serum levels could mean that there is a toxic amount of methotrexate building up in the body. The full effects of this interaction are still being studied, but for now the FDA has released a warning about taking methotrexate along with a PPI.  

Methotrexate may interact with the following medications:

  • Blood thinners (Coumadin)
  • Cyclosporine (Sandimmune, Neoral)
  • Digoxin (Lanoxin)
  • Etretinate (Tegison)
  • Phenytoin (Dilantin)
  • Probenecid
  • Proton pump inhibitors (PPIs)
  • Sulfa drugs (Bactrim)
  • Thiazide diuretics (Dyazide, hydrochlorothiazide)

Is Methotrexate Safe During Pregnancy?

The FDA has classified methotrexate as a type X drug. This means that studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. Methotrexate should not be used during pregnancy as it can cause a miscarriage or birth defects in an embryo. Men should discontinue methotrexate for at least 3 months before conception.

Women should discontinue methotrexate for one full ovulation cycle before conception. Methotrexate does pass into breast milk, and could affect a nursing infant. The FDA recommends that methotrexate not be used in women of childbearing age unless "there is clear medical evidence that the benefits can be expected to outweigh the considered risks."

How Long Can Methotrexate Be Taken Safely?

Methotrexate may take several weeks to be effective in treating Crohn’s disease. It should only be taken for a long period of time (months or years) under the close supervision of a physician.


Hospira, Inc. "Methotrexate Injection, USP." FDA.gov. Oct 2011.

Micromedex Consumer Medication Information. "Methotrexate (By mouth)." PubMed Health. Dec 2015.