Overview of Univfy's Prediction Tools: PreIVF and PredictIVF

IVF Success Rates 1,000 Times More Accurate Than Age-Based Statistics Alone

Age isn't the only factor to take into consideration when considering IVF.
Your IVF odds for success go beyond just your age or just your diagnosis. Life -- and IVF -- are more complicated than that. i love images Collection / Cultura / Getty Images

Will IVF work for you? If you’re considering IVF treatment, this is question has likely crossed your mind many times.

More so than with any other fertility treatment, just about every couple considering IVF wonders if the treatment will work for them, and whether it will be worth the financial, physical, and emotional cost to even try.

IVF is expensive, with the average couple paying $19,234 in out-of-pocket expenses during the course of treatment, and the average single cycle costing anywhere between $10,000 and $15,000.

A couple that can afford only one cycle may wonder if trying just once is worth it. A couple that has been through a failed cycle or two may question whether it’s worth trying again.

How do you know what your odds are, so you can decide?

You or your doctor can consult the current SART data, which can tell you what percentage of women your age conceived with IVF treatment.

But this is a one-dimensional look at your odds for success.

For example, you can have two women, both age 41, and one may have much better odds for success than the other. Or you can have two women age 23 and one may have significantly better (or worse) odds than the other.

This is where Univfy comes in. I spoke to Dr. Mylene Yao, co-founder and CEO of Univfy, and she totally sold me on how helpful Univfy can be for fertility patients and doctors.

The research behind Univfy’s technology is based on over 10,000 cycles for PreIVF, Univfy’s prediction tool for first-time IVF patients, and on over 20,000 cycles for PredictIVF, their tool for those who have gone through at least once IVF cycle, whether successfully or not.

The IVF cycles included in the research were performed at three excellent fertility clinics.  Each of these clinics – one in Boston, one in Canada, and one in Spain – receives different kinds of patients, which means a wider variety of patients are represented.

Univfy’s personalized IVF success statistics are 1,000 times more accurate than age-based statistics alone.

How Can Univfy Help Me Make Decisions Regarding IVF?

Univfy stands for unique IVF. Through sophisticated statistical analysis, Univfy’s tools take data provided by you to derive a more personalized IVF success rate.

In other words, instead of only considering your age, or only your diagnosis, Univfy’s IVF prediction technology takes into account multiple data points about you and your partner to give you a more accurate statistic. (See below for a list of what the technology takes into consideration.)

Their tools can also help you decide whether it would make more financial sense to pay for an IVF cycle at a time, purchase a multiple cycle packages, and try an IVF refund package.

Once you’ve provided your information to Univfy, you will receive your odds for successful treatment right away, along with an explanation of how those odds compare to other women.

How good do your odds need to be to proceed with IVF?

That’s something only you can decide.

No one can predict for certain whether IVF will work for you, and neither Univfy nor your doctor can tell you whether you should try IVF.

The decision to go forward with treatment is both a medical decision and a personal one.

At the end of the day, only you can decide what odds you’re comfortable with. What Univfy will give you is more accurate odds to make that decision on.

Who Might Be Interested in Univfy Tools?

Univfy has tools for those who have not yet attempted an IVF and for those that already have been through one or more failed cycles.

If you haven’t yet tried IVF, Univfy’s PreIVF tool will tell you what your odds are for success on your first cycle.

If you’ve already done one cycle of IVF, Univfy’s PredictIVF tool will take into account information from that cycle to help predict your odds for success if you try another.

These tools are created for fertility patient use.

You enter your fertility data into the tools yourself. You don’t need to go through any additional blood tests or ultrasounds, as your clinic likely has already completed a basic fertility work-up.

All you need to do is take the results from those fertility tests and enter them into the Univfy tool.

(If you don’t have all the information requested on hand, you can call up your fertility clinic and ask for it. It should all be in your records.)

The results you receive from Univfy are provided in an understandable format. You don’t need to be a doctor to understand the report.

Once you have your results, you should bring them to your doctor and discuss them.

Univfy also has a tool -- Univfy IVFsingle  -- that provides the statistical odds for having a multiple or twin birth if you get pregnant via IVF treatment. IVFsingle can help you and your doctor decide whether a single embryo transfer would be better for you.

However, this test is only available through select clinics. Ask your doctor whether they offer the Univfy IVFsingle test if you’re interested in this information.

What Information Does the Univfy Test Include In Its Analysis?

Univfy’s technology considers an impressive number of data points when coming up with your personalized IVF odds.

You should be able to get all the information you need for the Univfy tools from your fertility clinic.

The PreIVF tool – for women attempting their first IVF cycle -- takes into account...

Not required but optional information that can be included in the analysis include...

(More on understanding semen analysis results.)

If you’re looking at PredictIVF – the tool that’s used after you’ve gone through at least once IVF cycle – you’ll provide the above information AND also be asked to provide...

  • The total units of gonadotropins you took during the cycle
  • Whether you had an egg retrieval and how many eggs were retrieved
  • Whether you had an ICSI procedure performed
  • Whether you had assisted hatching (AH) performed
  • How many normally fertilized embryos there were
  • On the day 3 embryo culture, how many embryos had exactly 8 cells and how many had more than 8
  • On which day was the embryo transfer done
  • How many embryos were transferred and how many were cryopreserved
  • How many total IVF cycles you’ve gone through
  • How those cycles ended (with no live birth or with a live birth)
  • The result of your most recent IVF cycle

Optionally, you can also provide information on...

  • Your serum peak estradiol levels (Peak E2)
  • Your endometrial thickness recorded on the last ultrasound before egg retrieval
  • The number of blastocysts and frozen embryo blastocysts

Who Shouldn’t Use Univfy’s IVF Prediction Tools?

Univfy’s IVF tools are NOT for you if...

  • You are considering your first IVF cycle at age 43 years old or older.
  • You are considering your next IVF cycle at age 45 or older.
  • You had your first IVF cycle after age 43.
  • You’re not planning on using your own eggs. (In other words, you’re using donor eggs or donor embryos.)
  • Your day 3 FSH levels are over 14 U/L.
  • Your antral follicle count (AFC) is under 6. (Though you don’t need your AFC number to use Univfy; this data point is optional.)

If one of the above describes you, that doesn’t necessarily mean IVF treatment can’t be successful for you. In fact, using donor eggs for IVF has excellent success rates for many women.

There simply wasn’t a big enough sample size for women who met these criteria in the research.

Why Use Univfy if You Can Just Ask Your Doctor What Your Odds Are?

You should take into account both your doctor’s opinion and Univfy’s results. Neither should be considered alone, and here’s why.

What Univfy gives you that your doctor can’t is…

A personalized probability for IVF success that is based numerous data points. Univfy considers more than just your age, or just your diagnosis. The technology – which is based on over 10,000 cycles if you’re using PreIVF, and over 20,000 IVF cycles if you’re using PredictIVF -- considers more data points than any human could provide. 

An unbiased, statistically based analysis on your odds for success. Univfy does not benefit financially if you decide to go ahead with an IVF cycle, while your doctor does.

And, alternatively, if a clinic is worried about their success rates, Univfy has nothing to lose by telling you that your odds are better than average for your age.

What your doctor has that Univfy doesn’t is…

Information on your medical situation that isn’t included in Univfy’s analysis.  Univfy can only provide you with your odds based on the information requested by the tool. It can’t, for example, take into account another medical condition, like diabetes, or account for a rare cause of infertility.

Details on your personal life situation. Maybe you have a tremendous amount of stress in your life, or maybe your financial situation makes IVF a bad decision for your family. Your doctor can discuss this with you, while a computer tool cannot.

Neither your doctor nor the Univfy tools can account for every possible situation, which is why you should consider using both your doctor’s personal opinion and the technology based “opinion” when considering IVF treatment.

What if Your Doctor Says Your Odds Are Better or Worse Than Your Univfy Report?

Your doctor may be taking into account information that Univfy’s tool doesn’t have. Or, your doctor may have provided you with information based only on your age or diagnosis.

With your permission, your doctor can call Univfy to discuss your results.

What About Taking into Consideration Your Chosen Fertility Clinics Success Stats?

Univfy’s technology was based on cycles completed at three excellent fertility clinics: Boston IVF in Massachusetts, IVI-Valencia in Spain, and Ottawa Fertility Centre Canada.

Your Univfy results tell you what your odds for success would be in the best of hands, at a quality fertility clinic.

This is why you should always carefully research a fertility clinic before making a decision.

What Happens to the Information You Enter into the Univfy Tool?

Univfy’s system strictly adheres to medical privacy laws and maintains a secure website. The information you share on the site will not be shared with anyone else without your permission.

They do ask if you’d like to be considered for future research projects. You can answer yes or no. This doesn’t mean your information will be used in a research project, however.

If they are interested in using your data for a future research project, they will contact you at that time, and you can decline then if you wish. Your personal identifying information would not be connected in any way to the medical data used, and every research project they conduct first passes through an ethics committee.

Important note: You should always be aware of what information you share online. Sadly, there are a number of scam sites that are looking to steal information or money from fertility patients.

There are even some questionable sites online who claim to offer what Univfy is offering – personalized success rates for IVF and other fertility treatments. These sites may not have necessarily evil intent, but may not be worth your money or time.

Before you enter your personal information into these sites – or any site online – be sure to confirm it is legitimate and trustworthy.

How Much Do the Univfy Tools Cost?

Their IVF Success program cost $100, and allows you to take five Univfy tests over the course of a year.

This way, you can input data from each IVF cycle and receive your odds for success for your next cycle.

For example, you can input information for PreIVF before your first cycle. Then, after your first cycle, input information gleaned during that cycle into the PredictIVF tool to determine your odds for success if you try IVF again.

Their IVF cost calculators are free to use, but will be more accurate if you input your personalized IVF odds from the Univfy tools.

How Does Univfy Work With Fertility Clinics?

No matter which fertility clinic you choose, you can use the Univfy tools. You should take your report to your doctor, so they can use the information to help you.

With that said, there are some select fertility clinics who encourage their patients to use Univfy. Your clinic may provide information on Univfy in their welcome packet.

Univfy’s IVFsingle – the tool that analyzes a patient’s odds for conceiving multiples if they get pregnant during an IVF cycle -- is only available at participating clinics. Hopefully, it’ll soon be available to more clinics worldwide.

While Univfy’s main clientele are fertility patients, some clinics have reached out to Univfy, asking them to help them improve their success rates. Clinics who are interested should contact Univfy.

More on fertility treatment:

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Sources:

Banerjee P, Choi B, Shahine LK, Jun SH, O'Leary K, Lathi RB, Westphal LM, Wong WH, Yao MW. “Deep phenotyping to predict live birth outcomes in in vitro fertilization.” Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13570-5. doi: 10.1073/pnas.1002296107. Epub 2010 Jul 19.

Choi B, Bosch E, Lannon BM, Leveille MC, Wong WH, Leader A, Pellicer A, Penzias AS, Yao MW. “Personalized prediction of first-cycle in vitro fertilization success.” Fertil Steril. 2013 Jun;99(7):1905-11. doi: 10.1016/j.fertnstert.2013.02.016. Epub 2013 Mar 21.

Mylene W. Yao, MD. Co-founder and CEO of Univfy. Phone interview. August 12, 2014.

Univfy PreIVF Questionnaire Preview. Accessed August 25, 2014. https://www.univfy.com/sample/PreIVF_Questionnaire.pdf

Univfy PredictIVF Questionnaire Preview. Accessed August 25, 2014.  https://www.univfy.com/sample/PredictIVF_Questionnaire.pdf

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