Your Essential Guide to HIV Testing

The 10 Most Frequently Asked Questions About HIV Testing

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HIV-1 rapid fingerstick test. Image courtesy Alere, Inc.

When referring to the diagnostic tests associated with HIV, we often take that to mean the ubiquitous HIV test—or the test used to confirm whether or not we've been infected with the human immunodeficiency virus (or HIV). In fact, there are a number of different tests which are used in the detection, treatment and management of HIV, all of which can tell us

  • whether we are HIV-negative or HIV-positive.
  • when to start therapy and which drugs to use.
  • how effectively we are responding to therapy.
  • if any drug side effects are developing.
  • whether there is drug resistance building in our virus.

The importance of HIV testing has arguably never been greater. Today, it is estimated that of 1.2 million Americans living with HIV, a staggering 20-25% remain undiagnosed, while fewer than one-in-four are able to maintain an undetectable viral load vital to treatment success.

Therefore, it is important to understand what each of the tests entails, what they actually mean, and how they apply to you as an individual, whether you are HIV-positive or not.

1. Who Should Get an HIV Test (and When)?

It used to be that HIV testing was recommended only for those identified as being "at risk." In April 2013, all of that changed when the U.S. Preventive Services Task Force issued recommendations that all persons between the ages of 15 and 65 be screened for HIV as part of a routine doctor visit.

Learn why the new recommendations were made, what the research has shown, and how the benefits of early HIV testing far outweigh any potential downsides or concerns.

2. What Is the Preferred Method for HIV Testing in the U.S.?

On June 27, 2014, the Centers for Disease Control and Prevention (CDC) recommended a new strategy for HIV testing using 4th generation combination assays able to detect HIV infection up to four weeks earlier than current antibody-based tests.

Rather than relying solely on the detection of HIV antibodies (i.e., the defensive proteins produced in response to HIV), these combination assays are able to detect both antibodies and antigens.

3. What Are My HIV Testing Options?

Today, there a number of HIV testing options ranging from so-called "point-of-care" tests performed at a health facility to in-home rapid tests that provide you results in as little as 20 minutes.  Learn how each of these tests are performed, what their limitations are, and how they may be (or may not be) appropriate for your as an individual.

4. How Confidential Is HIV Testing?

Breach of confidentiality is often cited as the most salient reason for avoiding HIV testing among low-income, at-risk Americans. Despite laws designed to protect an individual’s health information, there still remains confusion as to where medical privacy begins and ends. Learn what your legal rights are and what you can do if you find that your privacy has been breached.  

5. How Often Do False Positives and False Negatives Occur?

Although the rate of false positive and false negative HIV test results is low, they do sometimes occur.

Learn why these anomalies occur, which tests are more prone to inaccurate results, and what you should know to ensure you get the most accurate results possible.

6. How Accurate Are In-Home HIV Tests?

According to the FDA, the OraQuick Rapid In-Home Test is not only safe and easy-to-use, but offers a sensitivity and specificity of roughly 95%—slightly less than the 99.3% and 99.8% seen with point-of-care kits used in clinics. However, unlike point-of-care tests, the in-home version is known to have a false negative rate of around 7%, meaning that one out of every 12 tests will deliver an incorrect "all clear" sign.

7. What Does My CD4 Count and Viral Load Mean?

In their most basic terms, the CD4 count measures the strength of a person’s immune function, while the viral load measures the amount of virus in a person’s body.  Learn what these values actually they tell us, how they relate to each other, and how proper monitoring can prevent the premature "virologic failure" of individuals on HIV therapy.

8. How Often Should I Get My CD4 and Viral Load Tested?

With the increased efficacy of modern antiretroviral therapy (ART), the emphasis should no longer be placed on using CD4 counts as the measure of ART success. According to guidelines issued by the U.S. Department of Health and Human Services (DHHS) on May 1, 2014, viral loads should alone be used to determine this, while CD4 counts may in some cases be considered optional.

9. What Do My Routine Blood Tests Mean?

When is a person is diagnosed with HIV, regular blood tests are performed as a course of therapy. These tests can be predictive of a developing infection or measure the person's response to the drugs themselves—detecting or even preventing side effects that sometimes occur. Learn what these tests mean and how, by understanding a few key values, you can better participate in the on-going management of your HIV.

10. What Are Genetic Resistance and Tropism Tests?

There are tests frequently used to determine whether a person is a candidate for a certain type drug therapy and/or what types of drug resistance have developed in the person’s so-called "viral pool." By performing these tests, doctors can effectively tailor the therapy to their patient, ensuring treatment durability and optimal treatment results.

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